N Mizoguchi1, Y Nishimura, H Ono, N Sakura. 1. Department of Paediatrics, Hiroshima University, Faculty of Medicine, 1-2-3, Kasumi, Minami-ku, Hiroshima, 734-8551, Japan. no-mizo@sj8.so-net.ne.jp
Abstract
UNLABELLED: Magnetic response imaging has demonstrated increased signal intensities within the basal ganglia in patients with hepatic encephalopathy; the densities are considered to represent manganese deposition. We measured whole blood manganese concentrations in nine children with congenital portosystemic venous shunts detected by screening tests for galactosaemia. Beyond 1 year of age, these patients showed significantly higher manganese concentrations than controls (2.40 +/- 0.43 versus 1.48 +/- 0.38 micrograms/dl; P = 0.0001). Four of the nine patients were studied by magnetic response imaging. T1-weighted images showed increased signal intensities in the basal ganglia of those four patients, suggesting manganese accumulation. CONCLUSION: Children with congenital portosystemic venous shunts showed manganese elevations in blood and magnetic response imaging changes in the basal ganglia. These children should avoid excessive manganese intake.
UNLABELLED: Magnetic response imaging has demonstrated increased signal intensities within the basal ganglia in patients with hepatic encephalopathy; the densities are considered to represent manganese deposition. We measured whole blood manganese concentrations in nine children with congenital portosystemic venous shunts detected by screening tests for galactosaemia. Beyond 1 year of age, these patients showed significantly higher manganese concentrations than controls (2.40 +/- 0.43 versus 1.48 +/- 0.38 micrograms/dl; P = 0.0001). Four of the nine patients were studied by magnetic response imaging. T1-weighted images showed increased signal intensities in the basal ganglia of those four patients, suggesting manganese accumulation. CONCLUSION:Children with congenital portosystemic venous shunts showed manganese elevations in blood and magnetic response imaging changes in the basal ganglia. These children should avoid excessive manganese intake.
Authors: Marta Sidoryk-Wegrzynowicz; Michal Wegrzynowicz; Eunsook Lee; Aaron B Bowman; Michael Aschner Journal: Toxicol Pathol Date: 2010-11-12 Impact factor: 1.902
Authors: Adam G Gow; Polly E Frowde; Clive M Elwood; Carolyn A Burton; Roger M Powell; Simon W Tappin; Rob D Foale; Andrew Duncan; Richard J Mellanby Journal: Metab Brain Dis Date: 2015-05-05 Impact factor: 3.584
Authors: Y Nishimura; G Tajima; A Dwi Bahagia; A Sakamoto; H Ono; N Sakura; K Naito; M Hamakawa; C Yoshii; M Kubota; K Kobayashi; T Saheki Journal: J Inherit Metab Dis Date: 2004 Impact factor: 4.982
Authors: Judy L Aschner; Adam Anderson; James Christopher Slaughter; Michael Aschner; Steven Steele; Amy Beller; Amanda Mouvery; Heather M Furlong; Nathalie L Maitre Journal: Am J Clin Nutr Date: 2015-11-11 Impact factor: 7.045
Authors: Mathieu Valcke; Marie-Hélène Bourgault; Sami Haddad; Michèle Bouchard; Denis Gauvin; Patrick Levallois Journal: Int J Environ Res Public Health Date: 2018-06-20 Impact factor: 3.390