Literature DB >> 11317226

Family-based association studies of monoaminergic gene polymorphisms among North Indians with schizophrenia.

P Semwal1, S Prasad, T Bhatia, S N Deshpande, J Wood, V L Nimgaonkar, B K Thelma.   

Abstract

Associations between schizophrenia and four candidate genes were tested among Indian patients with schizophrenia and their parents (DSM-IV criteria, n = 179 families). Polymorphisms within the genes encoding the serotonin 2A receptor (HT2A), tryptophan hydroxylase (TPH), catechol-O-methyl transferase (COMT) and dopamine transporter (DAT) were thus investigated. Two polymorphisms each were analyzed at HT2A and TPH, enabling haplotype-based analyses using the transmission disequilibrium test (TDT) for these genes. No significant associations were detected. Pooled analysis of samples like ours may be necessary to definitively exclude putative allelic associations at these loci.

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Year:  2001        PMID： 11317226     DOI： 10.1038/sj.mp.4000839

Source DB:  PubMed          Journal:  Mol Psychiatry        ISSN： 1359-4184            Impact factor:   15.992


  10 in total

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