AIM: To evaluate the effect of a high dose vitamin A and E supplementation on corneal re-epithelialisation time, visual acuity and haze following photorefractive keratectomy (PRK). METHODS: Two groups of 20 patients who underwent myopic PRK were supplemented with either 25 000 IU retinol palmitate and 230 mg alpha tocopheryl nicotinate or a placebo. Clinical outcomes were evaluated up to 360 days. RESULTS: In the vitamin treated group, re-epithelialisation time was significantly faster (p = 0.029) and haze incidence was reduced (p = 0.035), especially for high myopic corrections (p = 0.043). This group also reported a significantly better uncorrected visual acuity (p = 0.043). CONCLUSIONS: High dose vitamin A and E oral supplementation may accelerate re-epithelialisation time and may reduce corneal haze formation after PRK.
RCT Entities:
AIM: To evaluate the effect of a high dose vitamin A and E supplementation on corneal re-epithelialisation time, visual acuity and haze following photorefractive keratectomy (PRK). METHODS: Two groups of 20 patients who underwent myopic PRK were supplemented with either 25 000 IU retinol palmitate and 230 mg alpha tocopheryl nicotinate or a placebo. Clinical outcomes were evaluated up to 360 days. RESULTS: In the vitamin treated group, re-epithelialisation time was significantly faster (p = 0.029) and haze incidence was reduced (p = 0.035), especially for high myopic corrections (p = 0.043). This group also reported a significantly better uncorrected visual acuity (p = 0.043). CONCLUSIONS: High dose vitamin A and E oral supplementation may accelerate re-epithelialisation time and may reduce corneal haze formation after PRK.
Authors: R Brancato; N Schiavone; S Siano; A Lapucci; L Papucci; M Donnini; L Formigli; S Z Orlandini; G Carella; F Carones; S Capaccioli Journal: Eur J Ophthalmol Date: 2000 Jan-Mar Impact factor: 2.597
Authors: S Shimmura; T Masumizu; Y Nakai; K Urayama; J Shimazaki; H Bissen-Miyajima; M Kohno; K Tsubota Journal: Invest Ophthalmol Vis Sci Date: 1999-05 Impact factor: 4.799
Authors: S E Wilson; Q Li; J Weng; P A Barry-Lane; J V Jester; Q Liang; R J Wordinger Journal: Invest Ophthalmol Vis Sci Date: 1996-07 Impact factor: 4.799
Authors: Goran Bjelakovic; Dimitrinka Nikolova; Lise Lotte Gluud; Rosa G Simonetti; Christian Gluud Journal: Cochrane Database Syst Rev Date: 2012-03-14