Literature DB >> 11316585

Hypoxia-ischemia in fetal rabbit brain increases reactive nitrogen species production: quantitative estimation of nitrotyrosine.

S Tan1, R Bose, M Derrick.   

Abstract

Reactive nitrogen species (RNS) cause nitration of protein-bound tyrosine that is used as biomarker for detection. We hypothesized that RNS are formed in fetal rabbit brain following acute placental insufficiency. Near-term pregnant rabbits were randomized to either repetitive uterine ischemia or no ischemia, and fetal brains obtained. Only one electrochemical HPLC method (of three tested) was successful in detecting brain nitrotyrosine. Protein nitrotyrosine was significantly increased following cumulative 40 min ischemia and 20 min reperfusion compared to controls. Repetitive hypoxia-ischemia results in the increased formation of RNS in near-term fetal brains.

Entities:  

Mesh：

Substances：

Year:  2001        PMID： 11316585     DOI： 10.1016/s0891-5849(01)00499-3

Source DB:  PubMed          Journal:  Free Radic Biol Med        ISSN： 0891-5849            Impact factor:   7.376


  7 in total

1.  Normoxic resuscitation after cardiac arrest protects against hippocampal oxidative stress, metabolic dysfunction, and neuronal death.

Authors:  Viktoria Vereczki; Erica Martin; Robert E Rosenthal; Patrick R Hof; Gloria E Hoffman; Gary Fiskum
Journal:  J Cereb Blood Flow Metab       Date:  2006-06       Impact factor: 6.200

2.  Postischemic hyperoxia reduces hippocampal pyruvate dehydrogenase activity.

Authors:  Erica M Richards; Robert E Rosenthal; Tibor Kristian; Gary Fiskum
Journal:  Free Radic Biol Med       Date:  2006-02-17       Impact factor: 7.376

3.  Exploration of the active site of neuronal nitric oxide synthase by the design and synthesis of pyrrolidinomethyl 2-aminopyridine derivatives.

Authors:  Haitao Ji; Silvia L Delker; Huiying Li; Pavel Martásek; Linda J Roman; Thomas L Poulos; Richard B Silverman
Journal:  J Med Chem       Date:  2010-11-11       Impact factor: 7.446

4.  Hypoxia-ischemia causes persistent movement deficits in a perinatal rabbit model of cerebral palsy: assessed by a new swim test.

Authors:  Matthew Derrick; Alexander Drobyshevsky; Xinhai Ji; Lina Chen; Yirong Yang; Haitao Ji; Richard B Silverman; Sidhartha Tan
Journal:  Int J Dev Neurosci       Date:  2009-06-30       Impact factor: 2.457

5.  Impaired Na+,K+-ATPase activity as a mechanism of reactive nitrogen species-induced cytotoxicity in guinea pig liver exposed to lipopolysaccharides.

Authors:  Behzat Cimen; Nurten Türközkan; Ilgim Seven; Ali Unlü; Cimen Karasu
Journal:  Mol Cell Biochem       Date:  2004-04       Impact factor: 3.396

6.  Metformin treatment in the period after stroke prevents nitrative stress and restores angiogenic signaling in the brain in diabetes.

Authors:  Mohammed Abdelsaid; Roshini Prakash; Weiguo Li; Maha Coucha; Sherif Hafez; Maribeth H Johnson; Susan C Fagan; Adviye Ergul
Journal:  Diabetes       Date:  2014-12-18       Impact factor: 9.461

7.  Nitrotyrosine Density of Rabbit Urinary Bladder Muscle and Mucosa Measured via Western Blotting and 96-Well Plate Analysis.

Authors:  Brittany Fitzpatrick; Catherine Schuler; Robert E Leggett; Robert M Levin
Journal:  ISRN Urol       Date:  2012-02-29
  7 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.