Literature DB >> 11315760

Antidiabetic activity of a xanthone compound, mangiferin.

T Miura1, H Ichiki, I Hashimoto, N Iwamoto, M Kato, M Kubo, E Ishihara, Y Komatsu, M Okada, T Ishida, K Tanigawa.   

Abstract

Mangiferin (MF) isolated from Anemarrhena asphodeloides Bunge rhizome, was tested for antidiabetic activity in KK-Ay mice, an animal model of type-2 diabetes. MF lowered the blood glucose level of KK-Ay mice 3 weeks after oral administration (p < 0.01). However, no effect on the blood glucose level in normal mice was seen, indicating that MF could be useful in treating type-2 diabetes. In addition, MF improved hyperinsulinemia and, on insulin tolerance test, reduced blood glucose levels of KK-Ay mice. From these findings, it seems likely that MF exerts its antidiabetic activity by decreasing insulin resistance.

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Year:  2001        PMID： 11315760     DOI： 10.1078/0944-7113-00009

Source DB:  PubMed          Journal:  Phytomedicine        ISSN： 0944-7113            Impact factor:   5.340


  29 in total

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