Literature DB >> 11315635

Effect of IFN-gamma receptor gene deletion on vaccinia virus virulence.

V Sroller1, V Ludvíková, L Maresová, P Hainz, S Nĕmecková.   

Abstract

Two vaccina virus (VV) strains, WR and Praha, were selected for a study undertaken to determine whether the virus-encoded interferon-gamma receptor (IFN-gamma R) plays any role in virus virulence. Both of the viruses expressed the B8R gene coding for IFN-gamma R in infected cell cultures. The nucleotide sequence of the Praha virus B8R gene was determined, and, when compared with the published sequence of the WR virus, it only displayed one silent nucleotide substitution. Mutants of the WR and Praha viruses with deleted B8R gene were constructed. In rabbits, skin lesions produced by the WR B8R-deleted mutants were smaller and tended to disappear earlier than those caused by wild-type WR virus. Similar results were obtained with both independently prepared WR B8R-deleted mutants. These data strongly suggested that the product of B8R gene did play a role in virus virulence. A similar comparison of the wild-type Praha virus and its mutant could not be done because of the very low virulence of the parental virus for rabbits.

Entities:  

Mesh：

Substances：

Year:  2001        PMID： 11315635     DOI： 10.1007/s007050170172

Source DB:  PubMed          Journal:  Arch Virol        ISSN： 0304-8608            Impact factor:   2.574


  9 in total

Review 1.  Poxvirus immunomodulatory strategies: current perspectives.

Authors:  J B Johnston; Grant McFadden
Journal:  J Virol       Date:  2003-06       Impact factor: 5.103

2.  Poxvirus-encoded gamma interferon binding protein dampens the host immune response to infection.

Authors:  Isaac G Sakala; Geeta Chaudhri; R Mark Buller; Anthony A Nuara; Hongdong Bai; Nanhai Chen; Gunasegaran Karupiah
Journal:  J Virol       Date:  2007-01-17       Impact factor: 5.103

3.  Protective properties of vaccinia virus-based vaccines: skin scarification promotes a nonspecific immune response that protects against orthopoxvirus disease.

Authors:  Amanda D Rice; Mathew M Adams; Scott F Lindsey; Daniele M Swetnam; Brandi R Manning; Andrew J Smith; Andrew M Burrage; Greg Wallace; Amy L MacNeill; Richard W Moyer
Journal:  J Virol       Date:  2014-04-23       Impact factor: 5.103

4.  CD8 T cells use IFN-γ to protect against the lethal effects of a respiratory poxvirus infection.

Authors:  John Goulding; Georges Abboud; Vikas Tahiliani; Pritesh Desai; Tarun E Hutchinson; Shahram Salek-Ardakani
Journal:  J Immunol       Date:  2014-04-18       Impact factor: 5.422

5.  Rabbitpox virus and vaccinia virus infection of rabbits as a model for human smallpox.

Authors:  Mathew M Adams; Amanda D Rice; R W Moyer
Journal:  J Virol       Date:  2007-08-08       Impact factor: 5.103

6.  Host-range restriction of vaccinia virus E3L deletion mutant can be overcome in vitro, but not in vivo, by expression of the influenza virus NS1 protein.

Authors:  Susana Guerra; Fernando Abaitua; Luis Martínez-Sobrido; Mariano Esteban; Adolfo García-Sastre; Dolores Rodríguez
Journal:  PLoS One       Date:  2011-12-13       Impact factor: 3.240

7.  Susceptibility of the wild-derived inbred CAST/Ei mouse to infection by orthopoxviruses analyzed by live bioluminescence imaging.

Authors:  Jeffrey L Americo; Cindy L Sood; Catherine A Cotter; Jodi L Vogel; Thomas M Kristie; Bernard Moss; Patricia L Earl
Journal:  Virology       Date:  2013-11-28       Impact factor: 3.616

Review 8.  Modulating Vaccinia Virus Immunomodulators to Improve Immunological Memory.

Authors:  Jonas D Albarnaz; Alice A Torres; Geoffrey L Smith
Journal:  Viruses       Date:  2018-02-28       Impact factor: 5.048

Review 9.  The role of IL-12, IL-23 and IFN-gamma in immunity to viruses.

Authors:  Francesco Novelli; Jean-Laurent Casanova
Journal:  Cytokine Growth Factor Rev       Date:  2004-10       Impact factor: 7.638
  9 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.