H Kunugi1, S Nanko, R M Murray. 1. Department of Psychiatry, Teikyo University School of Medicine, 11-1, Kaga 2 Chrome, Itabashi-ku, Tokyo 173-8605, Japan. hkunugi@med.teikyo-u.ac.jp
Abstract
BACKGROUND: Many studies have shown an association between obstetric complications and schizophrenia. AIMS: To investigate the possible relationship between prenatal underdevelopment, neurodevelopmental abnormality and subsequent schizophrenia. METHOD: The literature was reviewed. In particular, by pooling data from recently published reports, we examined whether low birthweight (< 2500 g) is a risk factor for schizophrenia. RESULTS: Low birthweight was significantly more common for subjects with schizophrenia than for control subjects: P < 0.00001, odds ratio 2.6 (95% CI 2.0 to 3.3). Individuals born prematurely are at greater risk of perinatal brain damage and subsequent neurodevelopmental abnormalities, which may constitute vulnerability to the development of schizophrenia. Patients with schizophrenia who had low birthweights also tended to have poor premorbid psychosocial adjustment. CONCLUSIONS: Low birthweight is a modest, but definite, risk factor for schizophrenia. Brain damage associated with prenatal underdevelopment has a role in the pathogenesis of poor premorbid functioning and subsequent neurodevelopmental impairment in some cases of schizophrenia.
BACKGROUND: Many studies have shown an association between obstetric complications and schizophrenia. AIMS: To investigate the possible relationship between prenatal underdevelopment, neurodevelopmental abnormality and subsequent schizophrenia. METHOD: The literature was reviewed. In particular, by pooling data from recently published reports, we examined whether low birthweight (< 2500 g) is a risk factor for schizophrenia. RESULTS: Low birthweight was significantly more common for subjects with schizophrenia than for control subjects: P < 0.00001, odds ratio 2.6 (95% CI 2.0 to 3.3). Individuals born prematurely are at greater risk of perinatal brain damage and subsequent neurodevelopmental abnormalities, which may constitute vulnerability to the development of schizophrenia. Patients with schizophrenia who had low birthweights also tended to have poor premorbid psychosocial adjustment. CONCLUSIONS: Low birthweight is a modest, but definite, risk factor for schizophrenia. Brain damage associated with prenatal underdevelopment has a role in the pathogenesis of poor premorbid functioning and subsequent neurodevelopmental impairment in some cases of schizophrenia.
Authors: Emilio Fernandez-Egea; Brian Miller; Miguel Bernardo; Thomas Donner; Brian Kirkpatrick Journal: Schizophr Res Date: 2007-11-26 Impact factor: 4.939
Authors: Aditya Ambati; Ryan Hillary; Smaranda Leu-Semenescu; Hanna M Ollila; Ling Lin; Emmanuel H During; Neal Farber; Thomas J Rico; Juliette Faraco; Eileen Leary; Andrea N Goldstein-Piekarski; Yu-Shu Huang; Fang Han; Yakov Sivan; Michel Lecendreux; Pauline Dodet; Makoto Honda; Natan Gadoth; Sona Nevsimalova; Fabio Pizza; Takashi Kanbayashi; Rosa Peraita-Adrados; Guy D Leschziner; Rosa Hasan; Francesca Canellas; Kazuhiko Kume; Makrina Daniilidou; Patrice Bourgin; David Rye; José L Vicario; Birgit Hogl; Seung Chul Hong; Guiseppe Plazzi; Geert Mayer; Anne Marie Landtblom; Yves Dauvilliers; Isabelle Arnulf; Emmanuel Jean-Marie Mignot Journal: Proc Natl Acad Sci U S A Date: 2021-03-23 Impact factor: 11.205
Authors: Brian Kirkpatrick; Erick Messias; Philip D Harvey; Emilio Fernandez-Egea; Christopher R Bowie Journal: Schizophr Bull Date: 2007-12-21 Impact factor: 9.306