| Literature DB >> 11313418 |
E R Fedyk1, D Jones, H O Critchley, R P Phipps, T M Blieden, T A Springer.
Abstract
Stromal-derived factor-1 (SDF-1) is a CXC chemokine that is believed to be constitutively expressed by stromal cells of numerous tissues. In this report, we demonstrate that dermal fibroblasts and vessels of noninflamed tissues express SDF-1. Unexpectedly, we found that expression of SDF-1 is regulated by inflammation. Expression of SDF-1 by primary cultures of human gingival fibroblasts is potently inhibited by activated macrophages via secretion of IL-1alpha and TNF-alpha. Levels of SDF-1 mRNA also decrease in acutely inflamed mouse dermal wounds. We propose that SDF-1 functions as a homeostatic regulator of tissue remodeling, whose expression stabilizes existing dermal architecture.Entities:
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Year: 2001 PMID： 11313418 DOI： 10.4049/jimmunol.166.9.5749
Source DB: PubMed Journal: J Immunol ISSN： 0022-1767 Impact factor: 5.422