BACKGROUND: Caution should be exercised in treating patients with autoimmune diseases during pregnancy. CASES: We successfully treated three cases of Vogt-Koyanagi-Harada's disease (VKH disease) during pregnancy. OBSERVATIONS: In the second trimester (14-27 weeks) of 1 patient, inflammation was mild and could be treated by topical corticosteroid. There is the possibility that her immune response had been modified by pregnancy. Systemic corticosteroid in a high dose was administered to the two cases in the second and third trimesters of pregnancy (28-41 weeks). The severity of inflammation in these 2 patients was similar to that in nonpregnant women. Inflammation subsided immediately without recurrence in all cases. No abnormality was found during the deliveries or in the babies. CONCLUSIONS: Treatment for VKH disease during pregnancy should be chosen according to the severity of inflammation, the stage of pregnancy, and the maternal and fetal conditions.
BACKGROUND: Caution should be exercised in treating patients with autoimmune diseases during pregnancy. CASES: We successfully treated three cases of Vogt-Koyanagi-Harada's disease (VKH disease) during pregnancy. OBSERVATIONS: In the second trimester (14-27 weeks) of 1 patient, inflammation was mild and could be treated by topical corticosteroid. There is the possibility that her immune response had been modified by pregnancy. Systemic corticosteroid in a high dose was administered to the two cases in the second and third trimesters of pregnancy (28-41 weeks). The severity of inflammation in these 2 patients was similar to that in nonpregnant women. Inflammation subsided immediately without recurrence in all cases. No abnormality was found during the deliveries or in the babies. CONCLUSIONS: Treatment for VKH disease during pregnancy should be chosen according to the severity of inflammation, the stage of pregnancy, and the maternal and fetal conditions.
Authors: Arwa Z Alromaih; Abdullah I Almater; Abdulrahman F Albloushi; Norah F Alkheraiji; Ahmed M Abu El-Asrar Journal: Int Ophthalmol Date: 2022-08-09 Impact factor: 2.029
Authors: Mariana Ingolotti; Bernardo A Schlaen; Enrique Alfonso Roig Melo-Granados; Humberto Ruiz García; Jorge Arturo Aguilera Partida Journal: Am J Case Rep Date: 2019-03-07
Authors: Tunji S Oluleye; Adekunle O Rotimi-Samuel; Adetunji Adenekan; Olubanke T Ilo; Folashade B Akinsola; Adeola O Onakoya; Olufisayo T Aribaba; Adebukunola Adefule-Ositelu; Kareem O Musa; Yele Oyefeso Journal: Int Med Case Rep J Date: 2016-11-28