| Literature DB >> 11312623 |
T B Geijtenbeek1, S J van Vliet, G C van Duijnhoven, C G Figdor, Y van Kooyk.
Abstract
Dendritic cells (DC) capture micro-organisms that enter peripheral mucosal tissues and then migrate to secondary lymphoid organs, where they present in antigenic form to resting T cells and thus initiate adaptive immune responses. Here we describe the properties of a DC-specific C-type lectin, DC-SIGN, that is highly expressed on DC present in mucosal tissues and binds to the HIV-1 envelope glycoprotein gp120. DC-SIGN does not function as a receptor for viral entry into DC, but instead promotes efficient infection in trans of cells that express CD4 and chemokine receptors. The interaction of DC-SIGN with HIV gp120 may be an important target for therapeutic intervention and vaccine development. Copyright 2001 IFPA and Harcourt Publishers Ltd.Entities:
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Year: 2001 PMID： 11312623 DOI： 10.1053/plac.2001.0674
Source DB: PubMed Journal: Placenta ISSN： 0143-4004 Impact factor: 3.481