BACKGROUND: A biallelic polymorphism (--174 G/C) within the interleukin-6 (IL-6) promoter reportedly has functional importance through the modulation of IL-6 expression in vitro and in vivo. METHODS: We performed a population-based case-control study to analyse the association of the --174 G/C polymorphism with disease susceptibility and clinical manifestations in 211 German patients with systemic lupus erythematosus (SLE). RESULTS: There were no significant differences in allelic and genotypic frequencies between patients and healthy controls. Comparing patients with various disease manifestations, we found an association of the --174 G allele with discoid skin lesions (Pc=0.034) and anti-histone antibodies (Pc=0.009). CONCLUSIONS: The IL-6 promoter polymorphism --174 G/C does not contribute significantly to disease susceptibility, but predisposes to distinct clinical and immunological features. A genetically determined high IL-6 response may have a pathogenic role under these conditions.
BACKGROUND: A biallelic polymorphism (--174 G/C) within the interleukin-6 (IL-6) promoter reportedly has functional importance through the modulation of IL-6 expression in vitro and in vivo. METHODS: We performed a population-based case-control study to analyse the association of the --174 G/C polymorphism with disease susceptibility and clinical manifestations in 211 German patients with systemic lupus erythematosus (SLE). RESULTS: There were no significant differences in allelic and genotypic frequencies between patients and healthy controls. Comparing patients with various disease manifestations, we found an association of the --174 G allele with discoid skin lesions (Pc=0.034) and anti-histone antibodies (Pc=0.009). CONCLUSIONS: The IL-6 promoter polymorphism --174 G/C does not contribute significantly to disease susceptibility, but predisposes to distinct clinical and immunological features. A genetically determined high IL-6 response may have a pathogenic role under these conditions.
Authors: Maria José Santos; Diana Fernandes; Susana Capela; Jose Canas da Silva; João Eurico Fonseca Journal: Clin Rheumatol Date: 2010-12-14 Impact factor: 2.980
Authors: Tabrez Jafar; Suraksha Agrawal; Abbas Ali Mahdi; Raj Kumar Sharma; Shally Awasthi; G G Agarwal Journal: Indian J Clin Biochem Date: 2011-04-07
Authors: Maria Hristova; Lyubomir Dourmishev; Zornitsa Kamenarska; Svetla Nikolova; Radka Kaneva; Anton Vinkov; Marta Baleva; Daniela Monova; Vanio Mitev Journal: Biomed Res Int Date: 2013-09-11 Impact factor: 3.411