Literature DB >> 11312370

Human immunodeficiency virus type 1-specific immunity after genetic immunization is enhanced by modification of Gag and Pol expression.

Y Huang1, W P Kong , G J Nabel.   

Abstract

Immunity to human immunodeficiency virus virion-like structures or a polyprotein has been examined after DNA immunization with Rev-independent expression vectors. A Gag-Pol fusion protein stimulated cytotoxic T lymphocyte and antibody responses to Gag and Pol, while a Gag-Pol pseudoparticle did not elicit substantial Pol responses. This fusion protein may be useful for AIDS vaccines.

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Year:  2001        PMID： 11312370      PMCID： PMC114253          DOI： 10.1128/JVI.75.10.4947-4951.2001

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  29 in total

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3.  Increased expression and immunogenicity of sequence-modified human immunodeficiency virus type 1 gag gene.

Authors:  J zur Megede; M C Chen; B Doe; M Schaefer; C E Greer; M Selby; G R Otten; S W Barnett
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4.  A canarypox vaccine expressing multiple human immunodeficiency virus type 1 genes given alone or with rgp120 elicits broad and durable CD8+ cytotoxic T lymphocyte responses in seronegative volunteers.

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6.  Vaccine-induced cytotoxic T lymphocytes against human immunodeficiency virus type 1 using two complementary in vitro stimulation strategies.

Authors:  G J Gorse; G B Patel; M D Mandava; R B Belshe
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7.  Efficient lysis of human immunodeficiency virus type 1-infected cells by cytotoxic T lymphocytes.

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Journal:  J Virol       Date:  1996-09       Impact factor: 5.103

8.  Evaluation of novel human immunodeficiency virus type 1 Gag DNA vaccines for protein expression in mammalian cells and induction of immune responses.

Authors:  J T Qiu; R Song; M Dettenhofer; C Tian; T August; B K Felber; G N Pavlakis; X F Yu
Journal:  J Virol       Date:  1999-11       Impact factor: 5.103

9.  Recombinant modified vaccinia virus Ankara-simian immunodeficiency virus gag pol elicits cytotoxic T lymphocytes in rhesus monkeys detected by a major histocompatibility complex class I/peptide tetramer.

Authors:  A Seth; I Ourmanov; M J Kuroda; J E Schmitz; M W Carroll; L S Wyatt; B Moss; M A Forman; V M Hirsch; N L Letvin
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10.  In vivo gene delivery and stable transduction of nondividing cells by a lentiviral vector.

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Journal:  Science       Date:  1996-04-12       Impact factor: 47.728
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  54 in total

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5.  Neutralizing antibodies elicited by immunization of monkeys with DNA plasmids and recombinant adenoviral vectors expressing human immunodeficiency virus type 1 proteins.

Authors:  John R Mascola; Anna Sambor; Kristin Beaudry; Sampa Santra; Brent Welcher; Mark K Louder; Thomas C Vancott; Yue Huang; Bimal K Chakrabarti; Wing-Pui Kong; Zhi-Yong Yang; Ling Xu; David C Montefiori; Gary J Nabel; Norman L Letvin
Journal:  J Virol       Date:  2005-01       Impact factor: 5.103

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7.  HIV-1 Envelope Glycoprotein Trafficking through the Endosomal Recycling Compartment Is Required for Particle Incorporation.

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Review 8.  DNA vaccines against human immunodeficiency virus type 1 in the past decade.

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10.  Insulin-like growth factor II mRNA binding protein 1 associates with Gag protein of human immunodeficiency virus type 1, and its overexpression affects virus assembly.

Authors:  Yongdong Zhou; Liwei Rong; Jennifer Lu; Qinghua Pan; Chen Liang
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