Literature DB >> 11312365

Echoviruses bind heparan sulfate at the cell surface.

I G Goodfellow1, A B Sioofy, R M Powell, D J Evans.   

Abstract

Some echoviruses (EV) that bind decay-accelerating factor (DAF) also bind cells of human and murine origins in a DAF-independent manner. Pretreatment of cells with heparinase 1 or heparin blocks the binding of radiolabeled virus to the cell surface, and heparin prevents infection of rhabdomyosarcoma cells by certain EV, including several low-passage clinical isolates of EV 6 and some EV that do not bind DAF. These studies suggest that heparan sulfate may be of in vivo relevance as an attachment molecule for EV.

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Year:  2001        PMID： 11312365      PMCID： PMC114248          DOI： 10.1128/JVI.75.10.4918-4921.2001

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  31 in total

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Authors:  R M Powell; T Ward; D J Evans; J W Almond
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  35 in total

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