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Literature DB >> 11311993

Fluorocarbons and fluorinated amphiphiles in drug delivery and biomedical research.

Abstract

The specific properties of fluorocarbons, exceptional chemical and biological inertness, high gas-dissolving capacity, low surface tension, excellent spreading characteristics and high fluidity, have triggered numerous applications of these compounds in oxygen delivery. An injectable emulsion of fluorocarbon-in-water destined to deliver oxygen to tissues at risk of hypoxia has now completed Phase III clinical trials in Europe. A neat fluorocarbon is currently investigated in Phase II for treatment of acute respiratory failure by liquid ventilation. Fluorinated lipids and fluorinated surfactants can be used to elaborate and stabilize various colloidal systems, including different types of emulsions, vesicles and tubules, that also show promise for controlled release drug delivery.

Entities: Chemical Disease

Mesh：

Substances：

Year: 2001 PMID： 11311993 DOI： 10.1016/s0169-409x(01)00107-7

Source DB: PubMed Journal: Adv Drug Deliv Rev ISSN： 0169-409X Impact factor: 15.470

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Cited

59 in total

1. Fluorocapsules for improved function, immunoprotection, and visualization of cellular therapeutics with MR, US, and CT imaging.

Authors: Brad P Barnett; Jesús Ruiz-Cabello; Partha Hota; Robert Liddell; Piotr Walczak; Valerie Howland; Vadappuram P Chacko; Dara L Kraitchman; Aravind Arepally; Jeff W M Bulte
Journal: Radiology Date: 2010-10-22 Impact factor: 11.105

2. Amphiphilic hyperbranched fluoropolymers as nanoscopic 19F magnetic resonance imaging agent assemblies.

Authors: Wenjun Du; Andreas M Nyström; Lei Zhang; Kenya T Powell; Yali Li; Chong Cheng; Samuel A Wickline; Karen L Wooley
Journal: Biomacromolecules Date: 2008-09-17 Impact factor: 6.988

3. Encapsulation and release of Amphotericin B from an ABC triblock fluorous copolymer.

Authors: Jun-Pil Jee; Aaron McCoy; Sandro Mecozzi
Journal: Pharm Res Date: 2011-07-08 Impact factor: 4.200

Review 4. New frontiers and developing applications in 19F NMR.

Authors: Jian-Xin Yu; Rami R Hallac; Srinivas Chiguru; Ralph P Mason
Journal: Prog Nucl Magn Reson Spectrosc Date: 2012-11-02 Impact factor: 9.795

5. Self-Sorting and Coassembly of Fluorinated, Hydrogenated, and Hybrid Janus Dendrimers into Dendrimersomes.

Authors: Qi Xiao; Jack D Rubien; Zhichun Wang; Ellen H Reed; Daniel A Hammer; Dipankar Sahoo; Paul A Heiney; Srujana S Yadavalli; Mark Goulian; Samantha E Wilner; Tobias Baumgart; Sergei A Vinogradov; Michael L Klein; Virgil Percec
Journal: J Am Chem Soc Date: 2016-09-14 Impact factor: 15.419

Fluorocarbons and fluorinated amphiphiles in drug delivery and biomedical research.

1. Fluorocapsules for improved function, immunoprotection, and visualization of cellular therapeutics with MR, US, and CT imaging.

2. Amphiphilic hyperbranched fluoropolymers as nanoscopic 19F magnetic resonance imaging agent assemblies.

3. Encapsulation and release of Amphotericin B from an ABC triblock fluorous copolymer.

Review 4. New frontiers and developing applications in 19F NMR.

5. Self-Sorting and Coassembly of Fluorinated, Hydrogenated, and Hybrid Janus Dendrimers into Dendrimersomes.

6. Interaction of melittin peptides with perfluorocarbon nanoemulsion particles.

7. High lipophilicity of perfluoroalkyl carboxylate and sulfonate: implications for their membrane permeability.

8. Fluoropolymer-based emulsions for the intravenous delivery of sevoflurane.

9. Functional assessment of human dendritic cells labeled for in vivo (19)F magnetic resonance imaging cell tracking.

Review 10. Fluorine-containing nanoemulsions for MRI cell tracking.