| Literature DB >> 11311902 |
R X Moldrich1, P M Beart, D E Jane, A G Chapman, B S Meldrum.
Abstract
The 3,4-dicarboxyphenylglycines (3,4-DCPG) inhibit sound-induced seizures in DBA/2 mice with the racemate being notably more potent than either isomer (ED(50) (nmol, i.c.v.)): (RS)-3,4-DCPG (0.004; 86 mg/kg, i.p.)>>the mGlu(8) agonist (S)-3,4-DCPG (0.11)>the AMPA antagonist (R)-3,4-DCPG (0.38). A potentiation of anticonvulsant activity between AMPA and mGlu(8) receptors was confirmed by combining (R)-3,4-DCPG with the mGlu(8) agonist (RS)-4-phosphonophenylglycine. This potentiating mechanism provides a novel strategy for the treatment of epileptic seizures.Entities:
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Year: 2001 PMID： 11311902 DOI： 10.1016/s0028-3908(01)00002-8
Source DB: PubMed Journal: Neuropharmacology ISSN： 0028-3908 Impact factor: 5.250