Literature DB >> 11311597

Estrogen and the aging brain.

I Silva1, G Mor, F Naftolin.   

Abstract

Evidence is presented indicating a role for estrogen in the function and maintenance of the aging brain. Based on complementary data that estrogen regulates the function of the immune--brain barrier, the hypothesis is presented that estrogen contributes to brain homeostasis via regulation of microglial activation, enabling immune-privileged status in the brain. Diminished estrogen levels during the menopause compromise the immune--brain barrier fostering inflammatory processes in the brain. This has potentially lethal consequences for brain cells, and may contribute to brain pathologies such as Alzheimer's disease.

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Year:  2001        PMID： 11311597     DOI： 10.1016/s0378-5122(00)00195-x

Source DB:  PubMed          Journal:  Maturitas        ISSN： 0378-5122            Impact factor:   4.342


  9 in total

1.  Very low doses of heavy oxygen ion radiation induce premature ovarian failure.

Authors:  Birendra Mishra; Ryan Ripperdan; Laura Ortiz; Ulrike Luderer
Journal:  Reproduction       Date:  2017-05-20       Impact factor: 3.906

Review 2.  Effect of reproductive hormones and selective estrogen receptor modulators on mood during menopause.

Authors:  Claudio N Soares; Jennifer R Poitras; Jennifer Prouty
Journal:  Drugs Aging       Date:  2003       Impact factor: 3.923

3.  Follicle-stimulating hormone and estradiol interact to stimulate glutathione synthesis in rat ovarian follicles and granulosa cells.

Authors:  Yvonne D Hoang; Brooke N Nakamura; Ulrike Luderer
Journal:  Biol Reprod       Date:  2009-06-10       Impact factor: 4.285

4.  Charged iron particles, components of space radiation, destroy ovarian follicles.

Authors:  Birendra Mishra; Laura Ortiz; Ulrike Luderer
Journal:  Hum Reprod       Date:  2016-05-31       Impact factor: 6.918

5.  Antioxidant supplementation partially rescues accelerated ovarian follicle loss, but not oocyte quality, of glutathione-deficient mice†.

Authors:  Jinhwan Lim; Samiha Ali; Lisa S Liao; Emily S Nguyen; Laura Ortiz; Samantha Reshel; Ulrike Luderer
Journal:  Biol Reprod       Date:  2020-04-24       Impact factor: 4.285

Review 6.  Hormone replacement therapy to maintain cognitive function in women with dementia.

Authors:  Eva Hogervorst; Kristine Yaffe; Marcus Richards; Felicia A H Huppert
Journal:  Cochrane Database Syst Rev       Date:  2009-01-21

7.  Proposed Key Characteristics of Female Reproductive Toxicants as an Approach for Organizing and Evaluating Mechanistic Data in Hazard Assessment.

Authors:  Ulrike Luderer; Brenda Eskenazi; Russ Hauser; Kenneth S Korach; Cliona M McHale; Francisco Moran; Linda Rieswijk; Gina Solomon; Osamu Udagawa; Luoping Zhang; Marya Zlatnik; Lauren Zeise; Martyn T Smith
Journal:  Environ Health Perspect       Date:  2019-07-19       Impact factor: 9.031

8.  Exposure to environmentally relevant concentrations of ambient fine particulate matter (PM2.5) depletes the ovarian follicle reserve and causes sex-dependent cardiovascular changes in apolipoprotein E null mice.

Authors:  Ulrike Luderer; Jinhwan Lim; Laura Ortiz; Johnny D Nguyen; Joyce H Shin; Barrett D Allen; Lisa S Liao; Kelli Malott; Veronique Perraud; Lisa M Wingen; Rebecca J Arechavala; Bishop Bliss; David A Herman; Michael T Kleinman
Journal:  Part Fibre Toxicol       Date:  2022-01-07       Impact factor: 9.400

Review 9.  Opening up the window into "chemobrain": a neuroimaging review.

Authors:  Carole S Scherling; Andra Smith
Journal:  Sensors (Basel)       Date:  2013-03-06       Impact factor: 3.576
  9 in total

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