| Literature DB >> 11311493 |
T H Cheung1, M M Yu, K W Lo, S F Yim, T K Chung, Y F Wong.
Abstract
Amplification and overexpression of cyclin D1 and CDK4 genes in cervical carcinoma were studied by semi-quantitative differential polymerase chain reaction assay and an immunostaining technique, respectively. Amplifications of cyclin D1 and CDK4 genes were found in 24% (27/113) and 26% (29/112) of tumors, respectively. Overexpression of cyclin D1 and CDK4 was demonstrated in 32% (21/66) and 73% (45/62) of tumors, respectively. No tumor showed CDK4 gene mutation on single strand conformational polymorphism. Sixteen percent (8/49) of the tumor specimens showed neither amplification nor overexpression. Disease stage, tumor grade and overexpression of cyclin D1 were found to be independent poor prognostic factors in cervical carcinoma.Entities:
Mesh：
Substances：
Year: 2001 PMID： 11311493 DOI： 10.1016/s0304-3835(01)00457-8
Source DB: PubMed Journal: Cancer Lett ISSN： 0304-3835 Impact factor: 8.679