| Literature DB >> 11311140 |
M Wainszelbaum1, E Isola, S Wilkowsky, J J Cannata, J Florin-Christensen, M Florin-Christensen.
Abstract
We found that, as in African trypanosomes, endogenous phospholipase A(1) (Plase A(1)) activity can catalyse extensive deacylation of phospholipids upon cell death in all life stages of Trypanosoma cruzi. A major lysosomal Plase A(1) was purified and characterized. The enzyme products can explain the lesions surrounding degenerating T. cruzi cells in host tissues. Thus Plase A(1) emerges as a target to block pathogenesis in trypanosomal infections.Entities:
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Year: 2001 PMID： 11311140 PMCID： PMC1221793 DOI： 10.1042/bj3550765
Source DB: PubMed Journal: Biochem J ISSN： 0264-6021 Impact factor: 3.857