Literature DB >> 11309531

The role of inflammatory mediators in the failing heart: immunomodulation of cytokines in experimental models of heart failure.

A Matsumori1, S Sasayama.   

Abstract

Congestive heart failure may be produced by a variety of disorders, including dilated cardiomyopathy, hypertension, and ischemic heart disease. We have developed experimental models of these diseases, and found gene expressions of proinflammatory cytokines increased in the hearts of these animals. Various drugs for heart failure modulate the production of cytokines in experimental models of heart failure. Pimobendan, an inhibitor of phosphodiesterase III prolonged survival, attenuated inflammatory lesions, and decreased the production of cytokines and nitric oxide. Recent studies have shown that these inhibitory effects are due to inhibition of activation of NF-kappaB. In contrast, digitalis increased the production of cytokines and exacerbated myocarditis. Interleukin-10 prolonged survival, attenuated myocardial injury, and appears promising as a treatment of heart failure due to viral myocarditis. Endothelin-1 plays an important pathophysiological role in heart failure, and treatment with an endothelin antagonist had a cardioprotective effect in experimental models of heart failure.

Entities:  

Mesh：

Substances：

Year:  2001        PMID： 11309531     DOI： 10.1023/a:1011457910659

Source DB:  PubMed          Journal:  Heart Fail Rev        ISSN： 1382-4147            Impact factor:   4.214


  43 in total

1.  Serial circulating concentrations of C-reactive protein, interleukin (IL)-4, and IL-6 in patients with acute left heart decompensation.

Authors:  Y Sato; Y Takatsu; K Kataoka; T Yamada; R Taniguchi; S Sasayama; A Matsumori
Journal:  Clin Cardiol       Date:  1999-12       Impact factor: 2.882

2.  Effect of amiodarone on clinical status and left ventricular function in patients with congestive heart failure. CHF-STAT Investigators.

Authors:  B M Massie; S G Fisher; M Radford; P C Deedwania; B N Singh; R D Fletcher; S N Singh
Journal:  Circulation       Date:  1996-06-15       Impact factor: 29.690

3.  High doses of digitalis increase the myocardial production of proinflammatory cytokines and worsen myocardial injury in viral myocarditis: a possible mechanism of digitalis toxicity.

Authors:  A Matsumori; H Igata; K Ono; A Iwasaki; T Miyamoto; R Nishio; S Sasayama
Journal:  Jpn Circ J       Date:  1999-12

4.  Inotropic agents differentially inhibit the induction of nitric oxide synthase by endotoxin in cultured macrophages.

Authors:  A Matsumori; I Okada; T Shioi; Y Furukawa; T Nakamura; K Ono; A Iwasaki; S Sasayama
Journal:  Life Sci       Date:  1996       Impact factor: 5.037

5.  Negative inotropic effects of cytokines on the heart mediated by nitric oxide.

Authors:  M S Finkel; C V Oddis; T D Jacob; S C Watkins; B G Hattler; R L Simmons
Journal:  Science       Date:  1992-07-17       Impact factor: 47.728

6.  Beneficial effects of amlodipine in a murine model of congestive heart failure induced by viral myocarditis. A possible mechanism through inhibition of nitric oxide production.

Authors:  W Z Wang; A Matsumori; T Yamada; T Shioi; I Okada; S Matsui; Y Sato; H Suzuki; K Shiota; S Sasayama
Journal:  Circulation       Date:  1997-01-07       Impact factor: 29.690

7.  Elevated circulating levels of C-C chemokines in patients with congestive heart failure.

Authors:  P Aukrust; T Ueland; F Müller; A K Andreassen; I Nordøy; H Aas; J Kjekshus; S Simonsen; S S Frøland; L Gullestad
Journal:  Circulation       Date:  1998-03-31       Impact factor: 29.690

8.  Effects of intranasal administration of recombinant murine interferon-gamma on murine acute myocarditis caused by encephalomyocarditis virus.

Authors:  N Yamamoto; M Shibamori; M Ogura; Y Seko; M Kikuchi
Journal:  Circulation       Date:  1998-03-17       Impact factor: 29.690

9.  Transition from compensatory hypertrophy to dilated, failing left ventricles in Dahl salt-sensitive rats.

Authors:  M Inoko; Y Kihara; I Morii; H Fujiwara; S Sasayama
Journal:  Am J Physiol       Date:  1994-12

Review 10.  Myocardial contractile dysfunction in the systemic inflammatory response syndrome: role of a cytokine-inducible nitric oxide synthase in cardiac myocytes.

Authors:  D Ungureanu-Longrois; J L Balligand; R A Kelly; T W Smith
Journal:  J Mol Cell Cardiol       Date:  1995-01       Impact factor: 5.000
View more
  9 in total

Review 1.  Effects of supplementation with polyunsaturated fatty acids in patients with heart failure.

Authors:  Savina Nodari; Marco Triggiani; Alessandra Manerba; Giuseppe Milesi; Livio Dei Cas
Journal:  Intern Emerg Med       Date:  2011-10       Impact factor: 3.397

Review 2.  Dietary fat and heart failure: moving from lipotoxicity to lipoprotection.

Authors:  William C Stanley; Erinne R Dabkowski; Rogerio F Ribeiro; Kelly A O'Connell
Journal:  Circ Res       Date:  2012-03-02       Impact factor: 17.367

3.  Prevention and reversal of cardiac hypertrophy by soluble epoxide hydrolase inhibitors.

Authors:  Danyan Xu; Ning Li; Yuxia He; Valeriy Timofeyev; Ling Lu; Hsing-Ju Tsai; In-Hae Kim; Dipika Tuteja; Robertino Karlo P Mateo; Anil Singapuri; Benjamin B Davis; Reginald Low; Bruce D Hammock; Nipavan Chiamvimonvat
Journal:  Proc Natl Acad Sci U S A       Date:  2006-11-27       Impact factor: 11.205

Review 4.  The potential of soluble epoxide hydrolase inhibition in the treatment of cardiac hypertrophy.

Authors:  Todd R Harris; Ning Li; Nipanvan Chiamvimonvat; Bruce D Hammock
Journal:  Congest Heart Fail       Date:  2008 Jul-Aug

5.  Caspase inhibition protects against reovirus-induced myocardial injury in vitro and in vivo.

Authors:  Roberta L DeBiasi; Bridget A Robinson; Barbara Sherry; Ron Bouchard; R Dale Brown; Mona Rizeq; Carlin Long; Kenneth L Tyler
Journal:  J Virol       Date:  2004-10       Impact factor: 5.103

Review 6.  omega-3 polyunsaturated fatty acid supplementation for the treatment of heart failure: mechanisms and clinical potential.

Authors:  Monika K Duda; Karen M O'Shea; William C Stanley
Journal:  Cardiovasc Res       Date:  2009-05-27       Impact factor: 10.787

7.  Lack of chemokine signaling through CXCR5 causes increased mortality, ventricular dilatation and deranged matrix during cardiac pressure overload.

Authors:  Anne Waehre; Bente Halvorsen; Arne Yndestad; Cathrine Husberg; Ivar Sjaastad; Ståle Nygård; Christen P Dahl; M Shakil Ahmed; Alexandra V Finsen; Henrik Reims; William E Louch; Denise Hilfiker-Kleiner; Leif E Vinge; Borghild Roald; Håvard Attramadal; Martin Lipp; Lars Gullestad; Pål Aukrust; Geir Christensen
Journal:  PLoS One       Date:  2011-04-18       Impact factor: 3.240

8.  Interleukin-10 and Transforming Growth Factor Beta1 Gene Polymorphisms in Chronic Heart Failure.

Authors:  Mohammad Jafar Mahmoudi; Mona Hedayat; Mohammad Taghvaei; Sara Harsini; Ebrahim Nematipour; Nima Rezaei; Elham Farhadi; Maryam Mahmoudi; Maryam Sadr; Nilufar Esfahanian; Keramat Nourijelyani; Ali Akbar Amirzargar
Journal:  Acta Biomed       Date:  2019-05-23

9.  Successful use of mRNA-nucleofection for overexpression of interleukin-10 in murine monocytes/macrophages for anti-inflammatory therapy in a murine model of autoimmune myocarditis.

Authors:  Oliver Zimmermann; Jörg M Homann; Anna Bangert; Anna-Maria Müller; Georgi Hristov; Stefan Goeser; Juliane M Wiehe; Stefan Zittrich; Wolfgang Rottbauer; Jan Torzewski; Gabriele Pfitzer; Hugo A Katus; Ziya Kaya
Journal:  J Am Heart Assoc       Date:  2012-12-19       Impact factor: 5.501
  9 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.