Literature DB >> 11309321

Pharmacologic interruption of the mitogen-activated extracellular-regulated kinase/mitogen-activated protein kinase signal transduction pathway: potential role in promoting cytotoxic drug action.

P Dent1, S Grant.   

Abstract

Mesh：

Substances：

Year:  2001        PMID： 11309321

Source DB:  PubMed          Journal:  Clin Cancer Res        ISSN： 1078-0432            Impact factor:   12.531


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  21 in total

1.  The novel anti-MEK small molecule AZD6244 induces BIM-dependent and AKT-independent apoptosis in diffuse large B-cell lymphoma.

Authors:  Savita Bhalla; Andrew M Evens; Bojie Dai; Sheila Prachand; Leo I Gordon; Ronald B Gartenhaus
Journal:  Blood       Date:  2011-05-31       Impact factor: 22.113

2.  Activity of the multikinase inhibitor sorafenib in combination with cytarabine in acute myeloid leukemia.

Authors:  Shuiying Hu; Hongmei Niu; Hiroto Inaba; Shelley Orwick; Charles Rose; John C Panetta; Shengping Yang; Stanley Pounds; Yiping Fan; Christopher Calabrese; Jerold E Rehg; Dario Campana; Jeffrey E Rubnitz; Sharyn D Baker
Journal:  J Natl Cancer Inst       Date:  2011-04-12       Impact factor: 13.506

3.  ATM regulates a DNA damage response posttranscriptional RNA operon in lymphocytes.

Authors:  Krystyna Mazan-Mamczarz; Patrick R Hagner; Yongqing Zhang; Bojie Dai; Elin Lehrmann; Kevin G Becker; Jack D Keene; Myriam Gorospe; Zhenqui Liu; Ronald B Gartenhaus
Journal:  Blood       Date:  2011-01-05       Impact factor: 22.113

4.  Loss of Raf kinase inhibitor protein promotes cell proliferation and migration of human hepatoma cells.

Authors:  Han Chu Lee; Bo Tian; John M Sedivy; Jack R Wands; Miran Kim
Journal:  Gastroenterology       Date:  2006-10       Impact factor: 22.682

5.  Therapeutic targeting of the MEK/MAPK signal transduction module in acute myeloid leukemia.

Authors:  M Milella; S M Kornblau; Z Estrov; B Z Carter; H Lapillonne; D Harris; M Konopleva; S Zhao; E Estey; M Andreeff
Journal:  J Clin Invest       Date:  2001-09       Impact factor: 14.808

6.  Effects of methylglyoxal and glyoxalase I inhibition on breast cancer cells proliferation, invasion, and apoptosis through modulation of MAPKs, MMP9, and Bcl-2.

Authors:  Yi Guo; Yuning Zhang; Xunjun Yang; Panpan Lu; Xijuan Yan; Fanglan Xiao; Huaibin Zhou; Chaowei Wen; Mengru Shi; Jianxin Lu; Qing H Meng
Journal:  Cancer Biol Ther       Date:  2015-11-30       Impact factor: 4.742

Review 7.  Overcoming resistance to molecularly targeted anticancer therapies: Rational drug combinations based on EGFR and MAPK inhibition for solid tumours and haematologic malignancies.

Authors:  Giampaolo Tortora; Roberto Bianco; Gennaro Daniele; Fortunato Ciardiello; James A McCubrey; Maria Rosaria Ricciardi; Ludovica Ciuffreda; Francesco Cognetti; Agostino Tafuri; Michele Milella
Journal:  Drug Resist Updat       Date:  2007-05-07       Impact factor: 18.500

8.  MEK activation suppresses CPT11-induced apoptosis in rat intestinal epithelial cells through a COX-2-dependent mechanism.

Authors:  Youhei Horikawa; Michiro Otaka; Koga Komatsu; Mario Jin; Masaru Odashima; Isao Wada; Tamotsu Matsuhashi; Reina Ohba; Jinko Oyake; Natsumi Hatakeyama; Raymond N Dubois; Sumio Watanabe
Journal:  Dig Dis Sci       Date:  2007-03-28       Impact factor: 3.199

9.  RNAi-mediated downregulation of urokinase plasminogen activator receptor and matrix metalloprotease-9 in human breast cancer cells results in decreased tumor invasion, angiogenesis and growth.

Authors:  Sateesh Kunigal; Sajani S Lakka; Christopher S Gondi; Norman Estes; Jasti S Rao
Journal:  Int J Cancer       Date:  2007-11-15       Impact factor: 7.396

10.  CDK10 functions as a tumor suppressor gene and regulates survivability of biliary tract cancer cells.

Authors:  Jian-Hua Yu; Xiang-Yu Zhong; Wei-Guang Zhang; Zhi-Dong Wang; Qin Dong; Sheng Tai; Hui Li; Yun-Fu Cui
Journal:  Oncol Rep       Date:  2011-12-30       Impact factor: 3.906
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