Literature DB >> 11308264

Chronic hypoxia modulates tumour cell radioresponse through cytokine-inducible nitric oxide synthase.

D L Berge1, M De Ridder, V N Verovski, M Y Janssens, C Monsaert, G A Storme.   

Abstract

Chronic hypoxia up-regulated the mRNA and protein expression of inducible nitric oxide synthase (iNOS) in EMT-6 tumour cells exposed to interferon (IFN)-gamma and interleukin (IL)-I beta. Low concentrations of cytokines (1 unit ml(-1)) in 1% but not in 21% oxygen induced a remarkable increase in NO production and a 1.8-fold hypoxic cell radiosensitization. Therefore, chronic hypoxia may potentially be exploited to increase tumour cell radioresponse through the cytokine-inducible iNOS pathway. Copyright 2001 Cancer Research Campaign.

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Year:  2001        PMID： 11308264      PMCID： PMC2363861          DOI： 10.1054/bjoc.2000.1719

Source DB:  PubMed          Journal:  Br J Cancer        ISSN： 0007-0920            Impact factor:   7.640


  15 in total

1.  Induction and activity of nitric oxide synthase in cultured human intestinal epithelial monolayers.

Authors:  A Salzman; A G Denenberg; I Ueta; M O'Connor; S C Linn; C Szabó
Journal:  Am J Physiol       Date:  1996-04

2.  Radiosensitization of hypoxic tumor cells in vitro by nitric oxide.

Authors:  R J Griffin; C M Makepeace; W J Hur; C W Song
Journal:  Int J Radiat Oncol Biol Phys       Date:  1996-09-01       Impact factor: 7.038

3.  Radiation sensitisation by nitric oxide releasing agents.

Authors:  J B Mitchell; J A Cook; M C Krishna; W DeGraff; J Gamson; J Fisher; D Christodoulou; D A Wink
Journal:  Br J Cancer Suppl       Date:  1996-07

Review 4.  Hypoxia modulated gene expression: angiogenesis, metastasis and therapeutic exploitation.

Authors:  G U Dachs; G M Tozer
Journal:  Eur J Cancer       Date:  2000-08       Impact factor: 9.162

5.  Inducible nitric oxide synthase expression and erythropoietin production in human hepatocellular carcinoma cells.

Authors:  K Yoshioka; J Thompson; M J Miller; J W Fisher
Journal:  Biochem Biophys Res Commun       Date:  1997-03-27       Impact factor: 3.575

Review 6.  The molecular response of mammalian cells to hypoxia and the potential for exploitation in cancer therapy.

Authors:  G U Dachs; I J Stratford
Journal:  Br J Cancer Suppl       Date:  1996-07

7.  Intrinsic radiosensitivity of human pancreatic tumour cells and the radiosensitising potency of the nitric oxide donor sodium nitroprusside.

Authors:  V N Verovski; D L Van den Berge; G A Soete; B L Bols; G A Storme
Journal:  Br J Cancer       Date:  1996-12       Impact factor: 7.640

8.  Radiosensitization of hypoxic tumour cells by S-nitroso-N-acetylpenicillamine implicates a bioreductive mechanism of nitric oxide generation.

Authors:  M Y Janssens; V N Verovski; D L Van den Berge; C Monsaert; G A Storme
Journal:  Br J Cancer       Date:  1999-03       Impact factor: 7.640

9.  A hypoxia-responsive element mediates a novel pathway of activation of the inducible nitric oxide synthase promoter.

Authors:  G Melillo; T Musso; A Sica; L S Taylor; G W Cox; L Varesio
Journal:  J Exp Med       Date:  1995-12-01       Impact factor: 14.307

10.  Nitric oxide synthase activity in human breast cancer.

Authors:  L L Thomsen; D W Miles; L Happerfield; L G Bobrow; R G Knowles; S Moncada
Journal:  Br J Cancer       Date:  1995-07       Impact factor: 7.640
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  2 in total

1.  Nitric oxide synthase inhibition enhances the antitumor effect of radiation in the treatment of squamous carcinoma xenografts.

Authors:  Robert J G Cardnell; Ross B Mikkelsen
Journal:  PLoS One       Date:  2011-05-25       Impact factor: 3.240

2.  NF-kappaB inhibition impairs the radioresponse of hypoxic EMT-6 tumour cells through downregulation of inducible nitric oxide synthase.

Authors:  M De Ridder; D L Van den Berge; V N Verovski; C Monsaert; N Wauters; G A Storme
Journal:  Br J Cancer       Date:  2003-01-13       Impact factor: 7.640
  2 in total

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