Literature DB >> 11306294

LIS1: cellular function of a disease-causing gene.

R B Vallee1, C Tai, N E Faulkner.   

Abstract

Brain development is severely defective in children with lissencephaly. The highly organized distribution of neurons within the cerebral cortex is disrupted, a condition that might arise from improper migration of neuronal progenitors to their cortical destinations. Type I lissencephaly results from mutations in the LIS1 gene, which has been implicated in the cytoplasmic dynein and platelet-activating factor pathways. Recent studies have identified roles for the product of LIS1 in nuclear migration, mitotic spindle orientation and chromosome alignment, where it appears to act in concert with cytoplasmic dynein. A unifying hypothesis for the subcellular function of LIS1 is presented.

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Year:  2001        PMID： 11306294     DOI： 10.1016/s0962-8924(01)01956-0

Source DB:  PubMed          Journal:  Trends Cell Biol        ISSN： 0962-8924            Impact factor:   20.808


  27 in total

1.  LIS1, CLIP-170's key to the dynein/dynactin pathway.

Authors:  Frédéric M Coquelle; Michal Caspi; Fabrice P Cordelières; Jim P Dompierre; Denis L Dujardin; Cynthia Koifman; Patrick Martin; Casper C Hoogenraad; Anna Akhmanova; Niels Galjart; Jan R De Mey; Orly Reiner
Journal:  Mol Cell Biol       Date:  2002-05       Impact factor: 4.272

2.  A WD40 repeat protein regulates fungal cell differentiation and can be replaced functionally by the mammalian homologue striatin.

Authors:  Stefanie Pöggeler; Ulrich Kück
Journal:  Eukaryot Cell       Date:  2004-02

3.  Role of the nuclear migration protein Lis1 in cell morphogenesis in Ustilago maydis.

Authors:  Michael Valinluck; Sara Ahlgren; Mizuho Sawada; Kristopher Locken; Flora Banuett
Journal:  Mycologia       Date:  2010 May-Jun       Impact factor: 2.696

4.  A mammalian NudC-like protein essential for dynein stability and cell viability.

Authors:  Tianhua Zhou; Wendy Zimmerman; Xiaoqi Liu; Raymond L Erikson
Journal:  Proc Natl Acad Sci U S A       Date:  2006-06-05       Impact factor: 11.205

5.  NudEL targets dynein to microtubule ends through LIS1.

Authors:  Jun Li; Wei-Lih Lee; John A Cooper
Journal:  Nat Cell Biol       Date:  2005-06-19       Impact factor: 28.824

6.  Cytoplasmic LEK1 is a regulator of microtubule function through its interaction with the LIS1 pathway.

Authors:  Victor Soukoulis; Samyukta Reddy; Ryan D Pooley; Yuanyi Feng; Christopher A Walsh; David M Bader
Journal:  Proc Natl Acad Sci U S A       Date:  2005-06-06       Impact factor: 11.205

7.  Live imaging of Drosophila brain neuroblasts reveals a role for Lis1/dynactin in spindle assembly and mitotic checkpoint control.

Authors:  Karsten H Siller; Madeline Serr; Ruth Steward; Tom S Hays; Chris Q Doe
Journal:  Mol Biol Cell       Date:  2005-08-17       Impact factor: 4.138

8.  Regulation of cytoplasmic dynein ATPase by Lis1.

Authors:  Mariano T Mesngon; Cataldo Tarricone; Sachin Hebbar; Aimee M Guillotte; E William Schmitt; Lorene Lanier; Andrea Musacchio; Stephen J King; Deanna S Smith
Journal:  J Neurosci       Date:  2006-02-15       Impact factor: 6.167

9.  mNUDC is required for plus-end-directed transport of cytoplasmic dynein and dynactins by kinesin-1.

Authors:  Masami Yamada; Shiori Toba; Takako Takitoh; Yuko Yoshida; Daisuke Mori; Takeshi Nakamura; Atsuko H Iwane; Toshio Yanagida; Hiroshi Imai; Li-Yuan Yu-Lee; Trina Schroer; Anthony Wynshaw-Boris; Shinji Hirotsune
Journal:  EMBO J       Date:  2009-12-17       Impact factor: 11.598

10.  A new activity of doublecortin in recognition of the phospho-FIGQY tyrosine in the cytoplasmic domain of neurofascin.

Authors:  Krishnakumar Kizhatil; Yi-Xin Wu; Anindita Sen; Vann Bennett
Journal:  J Neurosci       Date:  2002-09-15       Impact factor: 6.167
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