Literature DB >> 11302825

Thalidomide inhibits granulocyte responses in healthy humans after ex vivo stimulation with bacterial antigens.

N P Juffermans1, A Verbon, M J Schultz, C E Hack, S J van Deventer, P Speelman, T van der Poll.   

Abstract

Ingestion of thalidomide was associated with a reduction in the upregulation of the granulocyte activation marker CD11b and a reduced capacity to release elastase and lactoferrin after stimulation with lipopolysaccharide or lipoteichoic acid. A single oral dose of thalidomide attenuates neutrophil activation upon ex vivo stimulation with bacterial antigens.

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Year:  2001        PMID： 11302825      PMCID： PMC90503          DOI： 10.1128/AAC.45.5.1547-1549.2001

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  14 in total

Review 1.  Thalidomide as an emerging immunotherapeutic agent.

Authors:  J B Marriott; G Muller; A G Dalgleish
Journal:  Immunol Today       Date:  1999-12

2.  Intravenous infusion of erythromycin inhibits CXC chemokine production, but augments neutrophil degranulation in whole blood stimulated with Streptococcus pneumoniae.

Authors:  M J Schultz; P Speelman; C E Hack; W A Buurman; S J van Deventer; T van Der Poll
Journal:  J Antimicrob Chemother       Date:  2000-08       Impact factor: 5.790

3.  Thalidomide suppresses Up-regulation of human immunodeficiency virus coreceptors CXCR4 and CCR5 on CD4+ T cells in humans.

Authors:  N P Juffermans; A Verbon; D P Olszyna; S J van Deventer; P Speelman; T van Der Poll
Journal:  J Infect Dis       Date:  2000-05-15       Impact factor: 5.226

4.  Lactoferrin turnover in man.

Authors:  R M Bennett; T Kokocinski
Journal:  Clin Sci (Lond)       Date:  1979-11       Impact factor: 6.124

Review 5.  Leukocyte traffic in the lung.

Authors:  J C Hogg; C M Doerschuk
Journal:  Annu Rev Physiol       Date:  1995       Impact factor: 19.318

Review 6.  Elastase in tissue injury.

Authors:  A Janoff
Journal:  Annu Rev Med       Date:  1985       Impact factor: 13.739

7.  A single oral dose of thalidomide enhances the capacity of lymphocytes to secrete gamma interferon in healthy humans.

Authors:  A Verbon; N P Juffermans; P Speelman; S J van Deventer; I J ten Berge; H J Guchelaar; T van der Poll
Journal:  Antimicrob Agents Chemother       Date:  2000-09       Impact factor: 5.191

8.  Effects of thalidomide on neutrophil respiratory burst, chemotaxis, and transmigration of cytokine- and endotoxin-activated endothelium.

Authors:  S Dunzendorfer; P Schratzberger; N Reinisch; C M Kähler; C J Wiedermann
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1997-11       Impact factor: 3.000

9.  Thalidomide and the immune system. 2. Changes in receptors on blood cells of a healthy volunteer.

Authors:  R Neubert; A C Nogueira; D Neubert
Journal:  Life Sci       Date:  1992       Impact factor: 5.037

10.  Plasma elastase alpha 1-antitrypsin and lactoferrin in sepsis: evidence for neutrophils as mediators in fatal sepsis.

Authors:  J H Nuijens; J J Abbink; Y T Wachtfogel; R W Colman; A J Eerenberg; D Dors; A J Kamp; R J Strack van Schijndel; L G Thijs; C E Hack
Journal:  J Lab Clin Med       Date:  1992-02
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