| Literature DB >> 11302486 |
K Gerth1, H Steinmetz, G Höfle, H Reichenbach.
Abstract
Nonproducer mutants support the assumption that epothilones A and B are synthesized by the same polyketide synthase (PKS). The endproducts of the PKS, epothilones C and D, compete for the active site of a constitutively synthesized monooxygenase which is regulated by product inhibition. The postulated C-13 hydroxy-epothilones as direct precursors of epothilones C and D were not detected.Entities:
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Year: 2001 PMID： 11302486 DOI： 10.7164/antibiotics.54.144
Source DB: PubMed Journal: J Antibiot (Tokyo) ISSN： 0021-8820 Impact factor: 2.649