Y Yoshizawa1, H Tanojo, S J Kim, H I Maibach. 1. Department of Dermatology, School of Medicine, University of California San Francisco, San Francisco, California, USA.
Abstract
BACKGROUND/AIMS: Ocean bathing has been considered "healthy" for skin, but its efficacy remains testimonial in nature. Our aim was to evaluate the effects of sea water and its main components on experimental irritant contact dermatitis induced by sodium lauryl sulphate (SLS) cumulative irritation. METHODS: After open application of 2% SLS for 10 min on volar forearm sites, solutions of sea water, 500 mM NaCl, 10 mM KCl, 55 mM MgCl2, 10 mM CaCl2, or deionized water were separately applied using filter paper discs for 20 min. The procedures were repeated daily for 2 weeks. The effects of the treatment were assessed daily using measurements of transepidermal water loss (TEWL), as an indicator of epidermal barrier function, and capacitance, as a parameter of stratum corneum water content. RESULTS: Sea water, NaCl, and KCl significantly inhibited the increase of TEWL as compared with deionized water (P < 0.003, P < 0.05, P < 0.05, respectively). Sea water and NaCl inhibited the decrease of capacitance as well (P < 0.03, P < 0.01). CONCLUSION: The effect of sea water may be attributed to skin barrier preservation by NaCl and KCl, and an emollient effect by NaCl.
RCT Entities:
BACKGROUND/AIMS: Ocean bathing has been considered "healthy" for skin, but its efficacy remains testimonial in nature. Our aim was to evaluate the effects of sea water and its main components on experimental irritant contact dermatitis induced by sodium lauryl sulphate (SLS) cumulative irritation. METHODS: After open application of 2% SLS for 10 min on volar forearm sites, solutions of sea water, 500 mM NaCl, 10 mM KCl, 55 mM MgCl2, 10 mM CaCl2, or deionized water were separately applied using filter paper discs for 20 min. The procedures were repeated daily for 2 weeks. The effects of the treatment were assessed daily using measurements of transepidermal water loss (TEWL), as an indicator of epidermal barrier function, and capacitance, as a parameter of stratum corneum water content. RESULTS:Sea water, NaCl, and KCl significantly inhibited the increase of TEWL as compared with deionized water (P < 0.003, P < 0.05, P < 0.05, respectively). Sea water and NaCl inhibited the decrease of capacitance as well (P < 0.03, P < 0.01). CONCLUSION: The effect of sea water may be attributed to skin barrier preservation by NaCl and KCl, and an emollient effect by NaCl.
Authors: Melanie Gorman Ng; John W Cherrie; Anne Sleeuwenhoek; Mark Stenzel; Richard K Kwok; Lawrence S Engel; Jennifer M Cavallari; Aaron Blair; Dale P Sandler; Patricia Stewart Journal: Ann Work Expo Health Date: 2019-07-23 Impact factor: 2.179