| Literature DB >> 11300350 |
H Wajcman1, A Lahary, D Promé, J Kister, J Riou, C Godart, C Préhu, J Traeger-Synodinos, I Papassotiriou, F Galactéros.
Abstract
Hb Mont Saint-Aignan [beta128(H6)Ala-->Pro] is a mildly unstable variant, associated with hemolytic anemia, marked microcytosis and increased alpha/beta biosynthetic ratio (1.55 versus 1.1 +/- 0.1 in the control). The abnormal chain was isolated by selective precipitation with isopropanol and the structural modification determined by protein chemistry methods (reversed phase high performance liquid chromatography and mass spectrometry). Possible mechanisms underlying the beta(+)-thalassemia-like expression of this variant are discussed.Entities:
Mesh：
Substances：
Year: 2001 PMID： 11300350 DOI： 10.1081/hem-100103070
Source DB: PubMed Journal: Hemoglobin ISSN： 0363-0269 Impact factor: 0.849