OBJECTIVE: As the strength of the association between the APOE epsilon4 allele and Alzheimer's disease (AD) varies across ethnic groups, we studied if there was such an association in Colombian patients. METHOD: We performed apolipoprotein E (APOE) genotyping in a clinical sample of 83 unrelated AD patients, predominantly late-onset (>65 yrs) including familial ( n =30) and sporadic AD cases (n= 53) diagnosed according to NINCDS-ADRDA criteria and assessed by a multi-disciplinary team. Control subjects (n = 44) had no significant cognitive impairment by medical interview and neuro-psychological testing. RESULTS: We found a high association (OR= 5.1 95%CI 1.9 -13.6) between APOE epsilon4 and AD, in this series with predominantly late-onset cases with familial aggregation in 24 cases (28.9%). A significant negative association was found between epsilon2 and AD (OR= 0.2 95% CI 0.05-0.75). CONCLUSION: Further population-based surveys in Colombia are warranted to precise a possible dose effect of APOE epsilon4.
OBJECTIVE: As the strength of the association between the APOE epsilon4 allele and Alzheimer's disease (AD) varies across ethnic groups, we studied if there was such an association in Colombian patients. METHOD: We performed apolipoprotein E (APOE) genotyping in a clinical sample of 83 unrelated ADpatients, predominantly late-onset (>65 yrs) including familial ( n =30) and sporadic AD cases (n= 53) diagnosed according to NINCDS-ADRDA criteria and assessed by a multi-disciplinary team. Control subjects (n = 44) had no significant cognitive impairment by medical interview and neuro-psychological testing. RESULTS: We found a high association (OR= 5.1 95%CI 1.9 -13.6) between APOE epsilon4 and AD, in this series with predominantly late-onset cases with familial aggregation in 24 cases (28.9%). A significant negative association was found between epsilon2 and AD (OR= 0.2 95% CI 0.05-0.75). CONCLUSION: Further population-based surveys in Colombia are warranted to precise a possible dose effect of APOE epsilon4.
Authors: Yu-Ping Sun; Bei Zhang; Lei Miao; Xian-Min Wang; Jia-Hui Yu; Li Luo; Lu Ying; Gao Xin; Gulinizha Haliakpaer; He Xia; Hua Yao Journal: Lipids Health Dis Date: 2015-04-12 Impact factor: 3.876
Authors: Michele L Gregório; Marcela A S Pinhel; Caroline L Sado; Gabriela S Longo; Fábio N Oliveira; Gisele S Amorim; Marcelo A Nakazone; Greiciane M Florim; Camila M Mazeti; Denise P Martins; Waldir A Tognola; Antonio C Brandão; Sidney Pinheiro Júnior; Moacir F de Godoy; Dorotéia R S Souza Journal: Biomed Res Int Date: 2013-09-24 Impact factor: 3.411
Authors: Olga Lucia Pedraza; Ana Maria Salazar Montes; Fabio Alexander Sierra; Maria Camila Montalvo; Yolanda Muñoz; Jose Miguel Díaz; Angela Lozano; Cesar Piñeros Journal: Dement Neuropsychol Date: 2017 Jul-Sep