| Literature DB >> 11297964 |
T Menges, P W Hermans, S G Little, T Langefeld, O Böning, J Engel, M Sluijter, R de Groot, G Hempelmann.
Abstract
A single base pair insertion/deletion (4G/SG) promoter polymorphism in the plasminogen-activator-inhibitor-1 (PAI-1) gene is thought to play a part in prognosis after severe trauma. We investigated the relation between outcome of severe trauma, PAI-1 concentrations, and PAP-1 genotype in 61 patients who had been severely injured. 11 (58%) of 19 patients with genotype 4G/4G did not survive, whereas only eight (28%) of 29 patients with heterozygous genotype 4G/SG, and two (15%) of 13 patients with genotype 5G/5G died. The PAI-1 4G allele is associated with high concentrations of PAI-1 in plasma and a poor survival rate after severe trauma.Entities:
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Year: 2001 PMID： 11297964 DOI： 10.1016/S0140-6736(00)04311-7
Source DB: PubMed Journal: Lancet ISSN： 0140-6736 Impact factor: 79.321