Literature DB >> 11297447

Discovery and optimization of a novel series of thrombin receptor (par-1) antagonists: potent, selective peptide mimetics based on indole and indazole templates.

H C Zhang1, C K Derian, P Andrade-Gordon, W J Hoekstra, D F McComsey, K B White, B L Poulter, M F Addo, W M Cheung, B P Damiano, D Oksenberg, E E Reynolds, A Pandey, R M Scarborough, B E Maryanoff.   

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Year:  2001        PMID： 11297447     DOI： 10.1021/jm000506s

Source DB:  PubMed          Journal:  J Med Chem        ISSN： 0022-2623            Impact factor:   7.446


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  12 in total

Review 1.  Proteinases and signalling: pathophysiological and therapeutic implications via PARs and more.

Authors:  R Ramachandran; M D Hollenberg
Journal:  Br J Pharmacol       Date:  2007-12-03       Impact factor: 8.739

2.  Pro-inflammatory secretory phospholipase A2 type IIA binds to integrins alphavbeta3 and alpha4beta1 and induces proliferation of monocytic cells in an integrin-dependent manner.

Authors:  Jun Saegusa; Nobuaki Akakura; Chun-Yi Wu; Case Hoogland; Zi Ma; Kit S Lam; Fu-Tong Liu; Yoko K Takada; Yoshikazu Takada
Journal:  J Biol Chem       Date:  2008-07-17       Impact factor: 5.157

Review 3.  The domino effect triggered by the tethered ligand of the protease activated receptors.

Authors:  Xu Han; Marvin T Nieman
Journal:  Thromb Res       Date:  2020-08-04       Impact factor: 3.944

4.  Characterization of Protease-Activated Receptor (PAR) ligands: Parmodulins are reversible allosteric inhibitors of PAR1-driven calcium mobilization in endothelial cells.

Authors:  Disha M Gandhi; Mark W Majewski; Ricardo Rosas; Kaitlin Kentala; Trevor J Foster; Eric Greve; Chris Dockendorff
Journal:  Bioorg Med Chem       Date:  2018-04-06       Impact factor: 3.641

5.  Protease-activated receptor-1 cleaved at R46 mediates cytoprotective effects.

Authors:  R A Schuepbach; J Madon; M Ender; P Galli; M Riewald
Journal:  J Thromb Haemost       Date:  2012-08       Impact factor: 5.824

6.  Protease-activated receptors in cancer: A systematic review.

Authors:  Na Han; Ketao Jin; Kuifeng He; Jiang Cao; Lisong Teng
Journal:  Oncol Lett       Date:  2011-04-08       Impact factor: 2.967

7.  Increased local expression of coagulation factor X contributes to the fibrotic response in human and murine lung injury.

Authors:  Chris J Scotton; Malvina A Krupiczojc; Melanie Königshoff; Paul F Mercer; Y C Gary Lee; Naftali Kaminski; John Morser; Joseph M Post; Toby M Maher; Andrew G Nicholson; James D Moffatt; Geoffrey J Laurent; Claudia K Derian; Oliver Eickelberg; Rachel C Chambers
Journal:  J Clin Invest       Date:  2009-08-03       Impact factor: 14.808

Review 8.  Procoagulant signalling mechanisms in lung inflammation and fibrosis: novel opportunities for pharmacological intervention?

Authors:  R C Chambers
Journal:  Br J Pharmacol       Date:  2008-01-28       Impact factor: 8.739

9.  A role for proteinase-activated receptor-1 in inflammatory bowel diseases.

Authors:  Nathalie Vergnolle; Laurie Cellars; Andrea Mencarelli; Giovanni Rizzo; Sunita Swaminathan; Paul Beck; Martin Steinhoff; Patricia Andrade-Gordon; Nigel W Bunnett; Morley D Hollenberg; John L Wallace; Giuseppe Cirino; Stefano Fiorucci
Journal:  J Clin Invest       Date:  2004-11       Impact factor: 14.808

10.  Proteinase-activated receptor-1, CCL2, and CCL7 regulate acute neutrophilic lung inflammation.

Authors:  Paul F Mercer; Andrew E Williams; Christopher J Scotton; Ricardo J José; Michal Sulikowski; James D Moffatt; Lynne A Murray; Rachel C Chambers
Journal:  Am J Respir Cell Mol Biol       Date:  2014-01       Impact factor: 6.914
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