| Literature DB >> 11295723 |
U H Ziegner1, H D Ochs, C Schanen, S A Feig, K Seyama, T Futatani, T Gross, M Wakim, R L Roberts, D J Rawlings, S Dovat, J K Fraser, E R Stiehm.
Abstract
Banked unrelated umbilical cord blood matched at 5 of 6 human leukocyte antigen loci was used to reconstitute the immune system in 2 brothers with X-linked lymphoproliferative syndrome and 1 boy with X-linked hyperimmunoglobulin-M syndrome. Pretransplant cytoreduction and posttransplant graft-versus-host prophylaxis were given. Hematopoietic engraftment and correction of the genetic defects were documented by molecular techniques. Two years after transplantation, all 3 patients have normal immune systems. These reports support the wider use of banked partially matched cord blood for transplantation in primary immunodeficiencies.Entities:
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Year: 2001 PMID： 11295723 DOI： 10.1067/mpd.2001.112511
Source DB: PubMed Journal: J Pediatr ISSN： 0022-3476 Impact factor: 4.406