Literature DB >> 11295540

Nicastrin, a presenilin-interacting protein, contains an aminopeptidase/transferrin receptor superfamily domain.

R Fagan1, M Swindells, J Overington, M Weir.   

Abstract

Nicastrin, a protein implicated in Alzheimer's disease, has a domain that is found in the aminopeptidase/transferrin receptor superfamily. In nicastrin, this domain might possess catalytic activity (as observed with aminopeptidases) or it could serve merely as a binding domain (with analogy to the transferrin receptors) for the beta-amyloid precursor protein.

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Year:  2001        PMID： 11295540     DOI： 10.1016/s0968-0004(01)01789-3

Source DB:  PubMed          Journal:  Trends Biochem Sci        ISSN： 0968-0004            Impact factor:   13.807


  14 in total

1.  Fungi and animals may share a common ancestor to nuclear receptors.

Authors:  Chris Phelps; Valentina Gburcik; Elena Suslova; Peter Dudek; Fedor Forafonov; Nathalie Bot; Morag MacLean; Richard J Fagan; Didier Picard
Journal:  Proc Natl Acad Sci U S A       Date:  2006-04-24       Impact factor: 11.205

2.  Nicalin and its binding partner Nomo are novel Nodal signaling antagonists.

Authors:  Christof Haffner; Mélanie Frauli; Stephanie Topp; Martin Irmler; Kay Hofmann; Jörg T Regula; Laure Bally-Cuif; Christian Haass
Journal:  EMBO J       Date:  2004-07-15       Impact factor: 11.598

3.  Effective function annotation through catalytic residue conservation.

Authors:  Richard A George; Ruth V Spriggs; Gail J Bartlett; Alex Gutteridge; Malcolm W MacArthur; Craig T Porter; Bissan Al-Lazikani; Janet M Thornton; Mark B Swindells
Journal:  Proc Natl Acad Sci U S A       Date:  2005-07-21       Impact factor: 11.205

Review 4.  Assembly, maturation, and trafficking of the gamma-secretase complex in Alzheimer's disease.

Authors:  Daniel R Dries; Gang Yu
Journal:  Curr Alzheimer Res       Date:  2008-04       Impact factor: 3.498

5.  Structure and Function of the γ-Secretase Complex.

Authors:  Michael S Wolfe
Journal:  Biochemistry       Date:  2019-06-25       Impact factor: 3.162

6.  Mutations in nicastrin protein differentially affect amyloid beta-peptide production and Notch protein processing.

Authors:  Annelie Pamrén; Johanna Wanngren; Lars O Tjernberg; Bengt Winblad; Ratan Bhat; Jan Näslund; Helena Karlström
Journal:  J Biol Chem       Date:  2011-07-18       Impact factor: 5.157

Review 7.  Toward structural elucidation of the gamma-secretase complex.

Authors:  Huilin Li; Michael S Wolfe; Dennis J Selkoe
Journal:  Structure       Date:  2009-03-11       Impact factor: 5.006

8.  Single chain variable fragment against nicastrin inhibits the gamma-secretase activity.

Authors:  Ikuo Hayashi; Sho Takatori; Yasuomi Urano; Hiroko Iwanari; Noriko Isoo; Satoko Osawa; Maiko A Fukuda; Tatsuhiko Kodama; Takao Hamakubo; Tong Li; Philip C Wong; Taisuke Tomita; Takeshi Iwatsubo
Journal:  J Biol Chem       Date:  2009-08-14       Impact factor: 5.157

9.  Glu-333 of nicastrin directly participates in gamma-secretase activity.

Authors:  Daniel R Dries; Sanjiv Shah; Yu-Hong Han; Cong Yu; Sophie Yu; Mark S Shearman; Gang Yu
Journal:  J Biol Chem       Date:  2009-09-03       Impact factor: 5.157

10.  Functional and genetic analysis of haplotypic sequence variation at the nicastrin genomic locus.

Authors:  Gillian Hamilton; Richard Killick; Jean-Charles Lambert; Philippe Amouyel; Minerva M Carrasquillo; V Shane Pankratz; Neill R Graff-Radford; Dennis W Dickson; Ronald C Petersen; Steven G Younkin; John F Powell; Richard Wade-Martins
Journal:  Neurobiol Aging       Date:  2012-03-08       Impact factor: 4.673
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