Literature DB >> 11295248

Distribution of 5-ht(5A), 5-ht(5B), 5-ht(6) and 5-HT(7) receptor mRNAs in the rat brain.

A M Kinsey1, A Wainwright, R Heavens, D J Sirinathsinghji, K R Oliver.   

Abstract

The precise involvement of 5-ht(5A), 5-ht(5B), 5-ht(6) and 5-HT(7) receptors in the pleiotropic actions of 5-HT remain incompletely known. To gain insights into their physiological function(s), localization of mRNAs encoding these subtypes was carried out using in situ hybridization on rat brain sections. Localization was heterogeneous. For example, 5-ht(5A) mRNA was widely expressed while 5-ht(5B) mRNA was predominantly expressed in habenula, hippocampus and inferior olive. 5-ht(6) mRNA was abundant in olfactory tubercles and caudate putamen, and highest levels of 5-HT(7) mRNA were observed in multiple thalamic nuclei. These data suggest that these receptors may have distinct functional roles within the serotonergic system.

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Year:  2001        PMID： 11295248     DOI： 10.1016/s0169-328x(01)00034-1

Source DB:  PubMed          Journal:  Brain Res Mol Brain Res        ISSN： 0169-328X


  29 in total

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