Literature DB >> 11294963

The diagnosis of leprosy is delayed in the United Kingdom.

D N Lockwood1, A J Reid.   

Abstract

Diagnostic delay in leprosy can have serious neurological consequences for the patient. We studied the presentation of leprosy patients, focusing on delays in diagnosis, in a retrospective case-note review of 28 patients referred to The Hospital for Tropical Diseases during 1995-1998. The median ages at onset of symptoms and at diagnosis were 25.1 years (range 9-77.7) and 30.1 years (range 9-78.3), respectively. The median time from symptom onset to diagnosis was 1.8 years (0.2-15.2). Prior to referral to a leprologist, patients had seen a dermatologist (20), neurologist (9), orthopaedic surgeon (5) and rheumatologist (2). Delay in diagnosis occurred in 82% of cases. Misdiagnoses as dermatological and neurological conditions were important causes of delay, and 68% of patients had nerve damage resulting in disability. Leprosy can be difficult to diagnose outside endemic areas. Increased awareness amongst general practitioners and hospital specialists would lead to more rapid diagnosis, thus minimizing damage and disability.

Entities:  

Mesh:

Year:  2001        PMID: 11294963     DOI: 10.1093/qjmed/94.4.207

Source DB:  PubMed          Journal:  QJM        ISSN: 1460-2393


  15 in total

1.  Painless needle prick on an erythematous plaque: a sign of leprosy.

Authors:  Francisco Vázquez-López; Leire Gonzalez-Lara
Journal:  CMAJ       Date:  2013-12-23       Impact factor: 8.262

2.  Arthritis, progressive maculopapular rash and severe peripheral neuropathy in a 60-year-old man. Diagnosis: Leprosy.

Authors:  François Tremblay; Martin Albert
Journal:  CMAJ       Date:  2013-12-23       Impact factor: 8.262

Review 3.  Leprosy in the 21st century.

Authors:  Cassandra White; Carlos Franco-Paredes
Journal:  Clin Microbiol Rev       Date:  2015-01       Impact factor: 26.132

Review 4.  Advances and hurdles on the way toward a leprosy vaccine.

Authors:  Malcolm S Duthie; Thomas P Gillis; Steven G Reed
Journal:  Hum Vaccin       Date:  2011-11-01

5.  The prevalence of ocular complications in leprosy patients seen in the United Kingdom over a period of 21 years.

Authors:  A N J Malik; R W Morris; T J Ffytche
Journal:  Eye (Lond)       Date:  2011-03-18       Impact factor: 3.775

6.  Specific IgG antibody responses may be used to monitor leprosy treatment efficacy and as recurrence prognostic markers.

Authors:  M S Duthie; M N Hay; E M Rada; J Convit; L Ito; L K M Oyafuso; M I P Manini; I M B Goulart; J Lobato; L R Goulart; D Carter; S G Reed
Journal:  Eur J Clin Microbiol Infect Dis       Date:  2011-05-05       Impact factor: 3.267

7.  Use of protein antigens for early serological diagnosis of leprosy.

Authors:  Malcolm S Duthie; Wakako Goto; Greg C Ireton; Stephen T Reece; Ludimila P V Cardoso; Celina M T Martelli; Mariane M A Stefani; Maria Nakatani; Robson Crusue de Jesus; Eduardo M Netto; Ma V F Balagon; Esterlina Tan; Robert H Gelber; Yumi Maeda; Masahiko Makino; Dan Hoft; Steven G Reed
Journal:  Clin Vaccine Immunol       Date:  2007-09-26

8.  Selection of antigens and development of prototype tests for point-of-care leprosy diagnosis.

Authors:  Malcolm S Duthie; Greg C Ireton; Ganga V Kanaujia; Wakako Goto; Hong Liang; Ajay Bhatia; Jean Marie Busceti; Murdo Macdonald; Kapil Dev Neupane; Chaman Ranjit; Bishwa Raj Sapkota; Marivic Balagon; Javan Esfandiari; Darrick Carter; Steven G Reed
Journal:  Clin Vaccine Immunol       Date:  2008-08-20

9.  Early Revelation of Leprosy in China by Sequential Antibody Analyses with LID-1 and PGL-I.

Authors:  Pan Qiong-Hua; Zheng Zhong-Yi; Yang Jun; Wen Yan; Yuan Lian-Chao; Li Huan-Ying; Steven G Reed; Malcolm S Duthie
Journal:  J Trop Med       Date:  2013-01-28

10.  Social participation of diabetes and ex-leprosy patients in the Netherlands and patient preference for combined self-care groups.

Authors:  Henry J C de Vries; Roos de Groot; Wim H van Brakel
Journal:  Front Med (Lausanne)       Date:  2014-08-18
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.