Literature DB >> 11294393

Water-soluble propofol analogues with intravenous anaesthetic activity.

A Cooke1, A Anderson, K Buchanan, A Byford, D Gemmell, N Hamilton, P McPhail, S Miller, H Sundaram, P Vijn.   

Abstract

Propofol (2,6-diisopropylphenol) is a widely used intravenous anaesthetic that is formulated as an emulsion since it lacks water solubility. We report a range of water-soluble analogues of propofol, containing a para-alkylamino substituent, which retain good intravenous anaesthetic activity in rodents.

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Year:  2001        PMID： 11294393     DOI： 10.1016/s0960-894x(01)00088-9

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  5 in total

Review 1.  Molecular approaches to improving general anesthetics.

Authors:  Stuart A Forman
Journal:  Anesthesiol Clin       Date:  2010-12

2.  4D-QSAR analysis of a set of propofol analogues: mapping binding sites for an anesthetic phenol on the GABA(A) receptor.

Authors:  Matthew D Krasowski; Xuan Hong; A J Hopfinger; Neil L Harrison
Journal:  J Med Chem       Date:  2002-07-18       Impact factor: 7.446

3.  Comparative molecular field analysis and synthetic validation of a hydroxyamide-propofol binding and functional block of neuronal voltage-dependent sodium channels.

Authors:  Milton L Brown; Hilary A Eidam; Mikell Paige; Paulianda J Jones; Manoj K Patel
Journal:  Bioorg Med Chem       Date:  2008-12-03       Impact factor: 3.641

4.  Monitored anesthesia care (MAC) sedation: clinical utility of fospropofol.

Authors:  Eric A Harris; David A Lubarsky; Keith A Candiotti
Journal:  Ther Clin Risk Manag       Date:  2009-12-29       Impact factor: 2.423

Review 5.  Development and Clinical Application of Phosphorus-Containing Drugs.

Authors:  Hanxiao Yu; He Yang; Enxue Shi; Wenjun Tang
Journal:  Med Drug Discov       Date:  2020-08-25
  5 in total

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