Literature DB >> 11294384

Synthesis of tetrocarcin derivatives with specific inhibitory activity towards Bcl-2 functions.

M Kaneko1, T Nakashima, Y Uosaki, M Hara, S Ikeda, Y Kanda.   

Abstract

Tetrocarcin A was recently identified as an inhibitor of the anti-apoptotic function of Bcl-2. We synthesized novel tetrocarcin derivatives in order to increase their selective inhibitory activity against Bcl-2. It was found that 21-acetoxy-9-glycosyloxy derivatives had potent Bcl-2 inhibitory activity without significant antimicrobial activity.

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Year:  2001        PMID： 11294384     DOI： 10.1016/s0960-894x(01)00094-4

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  11 in total

1.  Molecular recognition of protein surfaces: high affinity ligands for the CBP KIX domain.

Authors:  Stacey E Rutledge; Heather M Volkman; Alanna Schepartz
Journal:  J Am Chem Soc       Date:  2003-11-26       Impact factor: 15.419

2.  Elucidation of the kijanimicin gene cluster: insights into the biosynthesis of spirotetronate antibiotics and nitrosugars.

Authors:  Hua Zhang; Jess A White-Phillip; Charles E Melançon; Hyung-jin Kwon; Wei-luen Yu; Hung-wen Liu
Journal:  J Am Chem Soc       Date:  2007-11-07       Impact factor: 15.419

3.  Synthetic Strategies Toward the Decalin Motif of Maklamicin and Related Spirotetronates.

Authors:  Michelle H Lacoske; Jing Xu; Noel Mansour; Chao Gao; Emmanuel A Theodorakis
Journal:  Org Chem Front       Date:  2015-04-01       Impact factor: 5.281

4.  Cloning and characterization of the tetrocarcin A gene cluster from Micromonospora chalcea NRRL 11289 reveals a highly conserved strategy for tetronate biosynthesis in spirotetronate antibiotics.

Authors:  Jie Fang; Yiping Zhang; Lijuan Huang; Xinying Jia; Qi Zhang; Xu Zhang; Gongli Tang; Wen Liu
Journal:  J Bacteriol       Date:  2008-06-27       Impact factor: 3.490

5.  Apogossypolone, a nonpeptidic small molecule inhibitor targeting Bcl-2 family proteins, effectively inhibits growth of diffuse large cell lymphoma cells in vitro and in vivo.

Authors:  Yuan Sun; Jack Wu; Amro Aboukameel; Sanjeev Banerjee; Alan A Arnold; Jianyong Chen; Zaneta Nikolovska-Coleska; Yanqiong Lin; Xiaolan Ling; Dajun Yang; Shaomeng Wang; Ayad Al-Katib; Ramzi M Mohammad
Journal:  Cancer Biol Ther       Date:  2008-09-04       Impact factor: 4.742

Review 6.  Non-peptidic small molecule inhibitors against Bcl-2 for cancer therapy.

Authors:  Asfar S Azmi; Ramzi M Mohammad
Journal:  J Cell Physiol       Date:  2009-01       Impact factor: 6.384

7.  Concerning the selective protection of (Z)-1,5-syn-ene-diols and (E)-1,5-anti-ene-diols as allylic triethylsilyl ethers.

Authors:  Jacqueline D Hicks; Chan Woo Huh; Ashley D Legg; William R Roush
Journal:  Org Lett       Date:  2007-11-21       Impact factor: 6.005

8.  Structure-based discovery of a new class of Bcl-xL antagonists.

Authors:  Michele F Rega; Marilisa Leone; Dawoon Jung; Naomi J H Cotton; John L Stebbins; Maurizio Pellecchia
Journal:  Bioorg Chem       Date:  2007-05-21       Impact factor: 5.275

Review 9.  Spirotetronate polyketides as leads in drug discovery.

Authors:  Michelle H Lacoske; Emmanuel A Theodorakis
Journal:  J Nat Prod       Date:  2014-12-01       Impact factor: 4.050

Review 10.  Targeting Cell Survival Proteins for Cancer Cell Death.

Authors:  Manoj K Pandey; Sahdeo Prasad; Amit Kumar Tyagi; Lokesh Deb; Jiamin Huang; Deepkamal N Karelia; Shantu G Amin; Bharat B Aggarwal
Journal:  Pharmaceuticals (Basel)       Date:  2016-02-25
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