Literature DB >> 11294382

Synthesis and structure-activity relationships of 1-phenylpyrazoles as xanthine oxidase inhibitors.

S Ishibuchi1, H Morimoto, T Oe, T Ikebe, H Inoue, A Fukunari, M Kamezawa, I Yamada, Y Naka.   

Abstract

A series of 1-phenylpyrazoles was evaluated for inhibitory activity against xanthine oxidase in vitro. Of the compounds prepared, 1-(3-cyano-4-neopentyloxyphenyl)pyrazole-4-carboxylic acid (Y-700) had the most potent enzyme inhibition and displayed longer-lasting hypouricemic action than did allopurinol in a rat model of hyperuricemia induced by the uricase inhibitor potassium oxonate.

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Year:  2001        PMID： 11294382     DOI： 10.1016/s0960-894x(01)00093-2

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  10 in total

Review 1.  Therapeutic effects of xanthine oxidase inhibitors: renaissance half a century after the discovery of allopurinol.

Authors:  Pál Pacher; Alex Nivorozhkin; Csaba Szabó
Journal:  Pharmacol Rev       Date:  2006-03       Impact factor: 25.468

2.  A novel pseudo six-component synthesis of functionalized pyrazoles in ethanol by cascade reaction.

Authors:  Atieh Rezvanian; Maedeh Babashah; Maryam Anafcheh
Journal:  Mol Divers       Date:  2019-01-11       Impact factor: 2.943

3.  Rosehip inhibits xanthine oxidase activity and reduces serum urate levels in a mouse model of hyperuricemia.

Authors:  Hidetomo Kikuchi; Satomi Kogure; Rie Arai; Kouki Saino; Atsuko Ohkubo; Tadashi Tsuda; Katsuyoshi Sunaga
Journal:  Biomed Rep       Date:  2017-04-10

Review 4.  Serum uric acid-lowering therapies: where are we heading in management of hyperuricemia and the potential role of uricase.

Authors:  John S Bomalaski; Mike A Clark
Journal:  Curr Rheumatol Rep       Date:  2004-06       Impact factor: 4.592

5.  A 12-Week, Multicenter, Randomized, Double-Blind, Placebo-Controlled Clinical Trial for Evaluation of the Efficacy and Safety of DKB114 on Reduction of Uric Acid in Serum.

Authors:  Yu Hwa Park; Do Hoon Kim; Jung Suk Lee; Hyun Il Jeong; Kye Wan Lee; Tong Ho Kang
Journal:  Nutrients       Date:  2020-12-10       Impact factor: 5.717

Review 6.  The Role of Oxidative Stress in Hyperuricemia and Xanthine Oxidoreductase (XOR) Inhibitors.

Authors:  Ning Liu; Hu Xu; Qianqian Sun; Xiaojuan Yu; Wentong Chen; Hongquan Wei; Jie Jiang; Youzhi Xu; Wenjie Lu
Journal:  Oxid Med Cell Longev       Date:  2021-03-26       Impact factor: 6.543

7.  Identification of xanthine oxidase inhibitors through hierarchical virtual screening.

Authors:  Ying Yang; Lei Zhang; Jinying Tian; Fei Ye; Zhiyan Xiao
Journal:  RSC Adv       Date:  2020-07-24       Impact factor: 4.036

8.  Preferential inhibition of xanthine oxidase by 2-amino-6-hydroxy-8-mercaptopurine and 2-amino-6-purine thiol.

Authors:  Sukirti Kalra; Gopabandhu Jena; Kulbhushan Tikoo; Anup Kumar Mukhopadhyay
Journal:  BMC Biochem       Date:  2007-05-18       Impact factor: 4.059

9.  Synergistic Uric Acid-Lowering Effects of the Combination of Chrysanthemum indicum Linne Flower and Cinnamomum cassia (L.) J. Persl Bark Extracts.

Authors:  Young-Sil Lee; Eunjung Son; Seung-Hyung Kim; Yun Mi Lee; Ohn Soon Kim; Dong-Seon Kim
Journal:  Evid Based Complement Alternat Med       Date:  2017-07-09       Impact factor: 2.629

10.  DKB114, A Mixture of Chrysanthemum Indicum Linne Flower and Cinnamomum Cassia (L.) J. Presl Bark Extracts, Improves Hyperuricemia through Inhibition of Xanthine Oxidase Activity and Increasing Urine Excretion.

Authors:  Young-Sil Lee; Seung-Hyung Kim; Heung Joo Yuk; Dong-Seon Kim
Journal:  Nutrients       Date:  2018-09-28       Impact factor: 5.717
  10 in total

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