| Literature DB >> 11294380 |
S L Gwaltney1, H M Imade, K J Barr, Q Li, L Gehrke, R B Credo, R B Warner, J Y Lee, P Kovar, J Wang, M A Nukkala, N A Zielinski, D Frost, S C Ng, H L Sham.
Abstract
Sulfonate analogues of combretastatin A-4 have been prepared. These compounds compete with colchicine and combretastatin A-4 for the colchicine binding site on tubulin and are potent inhibitors of tubulin polymerization and cell proliferation. Importantly, these compounds also inhibit the proliferation of P-glycoprotein positive (+) cancer cells, which are resistant to many other antitumor agents.Entities:
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Year: 2001 PMID： 11294380 DOI： 10.1016/s0960-894x(01)00098-1
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823