| Literature DB >> 11294379 |
B W Trotter1, A G Quigley, W C Lumma, J T Sisko, E S Walsh, C S Hamann, R G Robinson, H Bhimnathwala, D G Kolodin, W Zheng, C A Buser, H E Huber, R B Lobell, N E Kohl, T M Williams, S L Graham, C J Dinsmore.
Abstract
A series of 2-arylindole-3-acetamide farnesyl protein transferase inhibitors has been identified. The compounds inhibit the enzyme in a farnesyl pyrophosphate-competitive manner and are selective for farnesyl protein transferase over the related enzyme geranylgeranyltransferase-I. A representative member of this series of inhibitors demonstrates equal effectiveness against HDJ-2 and K-Ras farnesylation in a cell-based assay when geranylgeranylation is suppressed.Entities:
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Year: 2001 PMID： 11294379 DOI： 10.1016/s0960-894x(01)00061-0
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823