A signal estimation approach to functional MRI.

In the last half decade, fast methods of magnetic resonance imaging have led to the possibility, for the first time, of non-invasive dynamic brain imaging. This has led to an explosion of work in the Neurosciences. From a signal processing viewpoint the problems are those of nonlinear spatio-temporal system identification. In this paper, we develop new methods of identification using novel spatial regularization. We also develop a new model comparison technique and use that to compare our method with existing techniques on some experimental data.