| Literature DB >> 11292876 |
N P Day1, C E Moore, M C Enright, A R Berendt, J M Smith, M F Murphy, S J Peacock, B G Spratt, E J Feil.
Abstract
Staphylococcus aureus is a major cause of severe infection in humans and yet is carried without symptoms by a large proportion of the population. We used multilocus sequence typing to characterize isolates of S. aureus recovered from asymptomatic nasal carriage and from episodes of severe disease within a defined population. We identified a number of frequently carried genotypes that were disproportionately common as causes of disease, even taking into account their relative abundance among carriage isolates. The existence of these ecologically abundant hypervirulent clones suggests that factors promoting the ecological fitness of this important pathogen also increase its virulence.Entities:
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Year: 2001 PMID： 11292876 DOI： 10.1126/science.1056495
Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728