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Literature DB >> 11292785

Dissociation of infectivity and pathogenicity in Borrelia burgdorferi.

V Thomas¹, J Anguita, S Samanta, P A Rosa, P Stewart, S W Barthold, E Fikrig.

Abstract

Clonal Borrelia burgdorferi N40 (cN40) passaged 75 times in vitro (N40-75) infects mice but does not cause disease. N40-75 passaged 45 times further in vitro (N40-120) was no longer infectious and lacked genes encoded on linear plasmids 38 and 28-1, among other differences. These data suggest that B. burgdorferi cN40, N40-75, and N40-120 have distinct phenotypes that can be used to dissect the genetic elements responsible for pathogenicity and infectivity.

Entities: Species

Mesh：

Year: 2001 PMID： 11292785 PMCID： PMC98321 DOI： 10.1128/IAI.69.5.3507-3509.2001

Source DB: PubMed Journal: Infect Immun ISSN： 0019-9567 Impact factor: 3.441

34 in total

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Journal: Infect Immun Date: 1994-05 Impact factor: 3.441

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Journal: Infect Immun Date: 1993-09 Impact factor: 3.441

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Journal: Infect Immun Date: 1992-11 Impact factor: 3.441

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Journal: Infect Immun Date: 1995-06 Impact factor: 3.441

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Journal: J Bacteriol Date: 1994-08 Impact factor: 3.490

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Journal: FEMS Microbiol Lett Date: 1994-11-01 Impact factor: 2.742

10. Borrelia burgdorferi OspA is an arthropod-specific transmission-blocking Lyme disease vaccine.

Authors: A M de Silva; S R Telford; L R Brunet; S W Barthold; E Fikrig
Journal: J Exp Med Date: 1996-01-01 Impact factor: 14.307

14 in total

1. The BBA01 protein, a member of paralog family 48 from Borrelia burgdorferi, is potentially interchangeable with the channel-forming protein P13.

Authors: Marija Pinne; Katrin Denker; Elin Nilsson; Roland Benz; Sven Bergström
Journal: J Bacteriol Date: 2006-06 Impact factor: 3.490

Review 2. Lyme Borreliosis: Is there a preexisting (natural) variation in antimicrobial susceptibility among Borrelia burgdorferi strains?

Authors: Emir Hodzic
Journal: Bosn J Basic Med Sci Date: 2015-07-08 Impact factor: 3.363

3. Borrelia burgdorferi linear plasmid 38 is dispensable for completion of the mouse-tick infectious cycle.

Authors: Daniel P Dulebohn; Aaron Bestor; Ryan O M Rego; Philip E Stewart; Patricia A Rosa
Journal: Infect Immun Date: 2011-06-27 Impact factor: 3.441

4. Borrelia burgdorferi-induced inflammation facilitates spirochete adaptation and variable major protein-like sequence locus recombination.

Authors: J Anguita; V Thomas; S Samanta; R Persinski; C Hernanz; S W Barthold; E Fikrig
Journal: J Immunol Date: 2001-09-15 Impact factor: 5.422

5. Borrelia burgdorferi changes its surface antigenic expression in response to host immune responses.

Authors: Fang Ting Liang; Jun Yan; M Lamine Mbow; Steven L Sviat; Robert D Gilmore; Mark Mamula; Erol Fikrig
Journal: Infect Immun Date: 2004-10 Impact factor: 3.441

6. The luxS gene is not required for Borrelia burgdorferi tick colonization, transmission to a mammalian host, or induction of disease.

Authors: Jon S Blevins; Andrew T Revel; Melissa J Caimano; Xiaofeng F Yang; James A Richardson; Kayla E Hagman; Michael V Norgard
Journal: Infect Immun Date: 2004-08 Impact factor: 3.441

7. The failure of immune response evasion by linear plasmid 28-1-deficient Borrelia burgdorferi is attributable to persistent expression of an outer surface protein.

Authors: Monica E Embers; Xavier Alvarez; Tara Ooms; Mario T Philipp
Journal: Infect Immun Date: 2008-07-14 Impact factor: 3.441

8. Plasmid stability during in vitro propagation of Borrelia burgdorferi assessed at a clonal level.

Authors: Dorothee Grimm; Abdallah F Elias; Kit Tilly; Patricia A Rosa
Journal: Infect Immun Date: 2003-06 Impact factor: 3.441

9. Passage through Ixodes scapularis ticks enhances the virulence of a weakly pathogenic isolate of Borrelia burgdorferi.

Authors: Sarojini Adusumilli; Carmen J Booth; Juan Anguita; Erol Fikrig
Journal: Infect Immun Date: 2009-10-12 Impact factor: 3.441

10. Linear and circular plasmid content in Borrelia burgdorferi clinical isolates.

Authors: Radha Iyer; Ogori Kalu; Joye Purser; Steven Norris; Brian Stevenson; Ira Schwartz
Journal: Infect Immun Date: 2003-07 Impact factor: 3.441