| Literature DB >> 1129271 |
S I Wasserman, D Whitmer, E J Geotzl, K F Austen.
Abstract
Purified human eosinophils demonstrate diminished chemotactic responsiveness (deactivation) after incubation with the eosinophil chemotactic factor of anaphylaxis (ECF-A). The deactivation is rapid and selective in that ECF-A deactivated human eosinophils more markedly than neutrophilic or mononuclear leukocytes. The eosinophil can also be deactivated by C5a which is eosinophilotactic, and there is cross deactivation between C5a and ECF-A. Deactivation may be an important physiologic control mechanism enabling the eosinophil to remain at sites of ECF-A release in order to manifest its regulatory functions in immediate hypersensitivity reactions.Entities:
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Year: 1975 PMID： 1129271 DOI： 10.3181/00379727-148-38527
Source DB: PubMed Journal: Proc Soc Exp Biol Med ISSN： 0037-9727