Literature DB >> 11291246

The molecular biology of hepatitis C virus. Genotypes and quasispecies.

X Forns1, J Bukh.   

Abstract

Hepatitis C virus (HCV) is an important cause of chronic liver disease worldwide. HCV is a positive-strand genotype RNA virus with extensive genetic heterogeneity; HCV isolates define 6 major genotypes, and HCV circulates within an infected individual as a number of closely related but distinct species, termed a quasispecies. This article reviews characteristic aspects of HCV molecular biology and their implications for treatment and vaccine development.

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Year:  1999        PMID： 11291246     DOI： 10.1016/s1089-3261(05)70234-8

Source DB:  PubMed          Journal:  Clin Liver Dis        ISSN： 1089-3261            Impact factor:   6.126


  24 in total

1.  Molecular characterization of a full genome Turkish hepatitis C virus 1b isolate (HCV-TR1): a predominant viral form in Turkey.

Authors:  Esra Yildiz; Asli Oztan; Funda Sar; Ergun Pinarbasi; Rengul Cetin-Atalay; Hikmet Akkiz; Mehmet Ozturk
Journal:  Virus Genes       Date:  2002-10       Impact factor: 2.332

2.  Analysis of quasispecies in the viral 5' untranslated region of hepatitis C virus to evaluate ribavirin mutagenic effect in patients receiving ribavirin and interferon-alfa.

Authors:  A Vallejo; S Molina-Pinelo; M A Abad; G Gómez; M Leal; A Sánchez-Quijano; E Lissen
Journal:  Eur J Clin Microbiol Infect Dis       Date:  2004-12       Impact factor: 3.267

3.  Development of a novel dicistronic reporter-selectable hepatitis C virus replicon suitable for high-throughput inhibitor screening.

Authors:  Weidong Hao; Koleen J Herlihy; Noelle Jie Zhang; Shella A Fuhrman; Chau Doan; Amy K Patick; Rohit Duggal
Journal:  Antimicrob Agents Chemother       Date:  2006-10-23       Impact factor: 5.191

4.  Hepatitis C Virus in Pregnancy and Early Childhood: Current Understanding and Knowledge Deficits.

Authors:  Ravi Jhaveri; Geeta K Swamy
Journal:  J Pediatric Infect Dis Soc       Date:  2014-09       Impact factor: 3.164

5.  Oxidative Stress Attenuates Lipid Synthesis and Increases Mitochondrial Fatty Acid Oxidation in Hepatoma Cells Infected with Hepatitis C Virus.

Authors:  Donna N Douglas; Christopher Hao Pu; Jamie T Lewis; Rakesh Bhat; Anwar Anwar-Mohamed; Michael Logan; Garry Lund; William R Addison; Richard Lehner; Norman M Kneteman
Journal:  J Biol Chem       Date:  2015-12-01       Impact factor: 5.157

6.  Disruption of hepatitis C virus RNA replication through inhibition of host protein geranylgeranylation.

Authors:  Jin Ye; Chunfu Wang; Rhea Sumpter; Michael S Brown; Joseph L Goldstein; Michael Gale
Journal:  Proc Natl Acad Sci U S A       Date:  2003-12-10       Impact factor: 11.205

7.  Genetic variation of hepatitis C virus in a cohort of injection heroin users in Wuhan, China.

Authors:  Jin-Song Peng; Xu Wang; Man-Qing Liu; Dun-Jin Zhou; Jie Gong; Han-Ming Xu; Jian-Ping Chen; Hong-Hao Zhu; Wang Zhou; Wen-Zhe Ho
Journal:  Virus Res       Date:  2008-03-18       Impact factor: 3.303

8.  Human combinatorial libraries yield rare antibodies that broadly neutralize hepatitis C virus.

Authors:  Daniel X Johansson; Cécile Voisset; Alexander W Tarr; Mie Aung; Jonathan K Ball; Jean Dubuisson; Mats A A Persson
Journal:  Proc Natl Acad Sci U S A       Date:  2007-10-02       Impact factor: 11.205

9.  Specific polymorphisms in hepatitis C virus genotype 3 core protein associated with intracellular lipid accumulation.

Authors:  Ravi Jhaveri; John McHutchison; Keyur Patel; Guan Qiang; Anna Mae Diehl
Journal:  J Infect Dis       Date:  2008-01-15       Impact factor: 5.226

10.  Genetic diversity of NS5A protein from hepatitis C virus genotype 3a and its relationship to therapy response.

Authors:  Cíntia Bittar; Ana Carolina G Jardim; Lilian H T Yamasaki; Artur T L de Queiróz; Claudia M A Carareto; João Renato R Pinho; Isabel Maria V G de Carvalho-Mello; Paula Rahal
Journal:  BMC Infect Dis       Date:  2010-02-23       Impact factor: 3.090
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