Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 The C. elegans gon-2 gene encodes a putative TRP cation channel protein required for mitotic cell cycle progression.

Literature DB >> 11290424

The C. elegans gon-2 gene encodes a putative TRP cation channel protein required for mitotic cell cycle progression.

R J West¹, A Y Sun, D L Church, E J Lambie.

Abstract

The C. elegans gon-2 gene is required for the post-embryonic mitotic cell divisions of the gonadal precursor cells. A single major transcript of approximately 6.7 kb is derived from the gon-2 locus. This mRNA encodes a protein related to the TRP family of cation channels and has a high degree of similarity to several vertebrate genes, including melastatin. Mutant alleles of gon-2 affect evolutionarily conserved amino acid residues. Northern analyses suggest that gon-2 expression is not limited to gonadal tissues.

Entities: Chemical Gene Species

Mesh：

Substances：

Year: 2001 PMID： 11290424 DOI： 10.1016/s0378-1119(01)00373-0

Source DB: PubMed Journal: Gene ISSN： 0378-1119 Impact factor: 3.688

Keyword Cloud
Cited

15 in total

1. Regulation of melastatin, a TRP-related protein, through interaction with a cytoplasmic isoform.

Authors: X Z Xu; F Moebius; D L Gill; C Montell
Journal: Proc Natl Acad Sci U S A Date: 2001-09-04 Impact factor: 11.205

Review 2. Emerging roles of TRPM6/TRPM7 channel kinase signal transduction complexes.

Authors: V Chubanov; M Mederos y Schnitzler; J Wäring; A Plank; T Gudermann
Journal: Naunyn Schmiedebergs Arch Pharmacol Date: 2005-04 Impact factor: 3.000

3. Differential regulation of TRPM channels governs electrolyte homeostasis in the C. elegans intestine.

Authors: Takayuki Teramoto; Eric J Lambie; Kouichi Iwasaki
Journal: Cell Metab Date: 2005-05 Impact factor: 27.287

Review 4. Invertebrate TRP proteins as functional models for mammalian channels.

Authors: Joris Vriens; Grzegorz Owsianik; Thomas Voets; Guy Droogmans; Bernd Nilius
Journal: Pflugers Arch Date: 2004-12 Impact factor: 3.657

5. Magnesium excretion in C. elegans requires the activity of the GTL-2 TRPM channel.

Authors: Takayuki Teramoto; Laura A Sternick; Eriko Kage-Nakadai; Shirine Sajjadi; Jakub Siembida; Shohei Mitani; Kouichi Iwasaki; Eric J Lambie
Journal: PLoS One Date: 2010-03-08 Impact factor: 3.240

6. The promotion of gonadal cell divisions by the Caenorhabditis elegans TRPM cation channel GON-2 is antagonized by GEM-4 copine.

Authors: Diane L Church; Eric J Lambie
Journal: Genetics Date: 2003-10 Impact factor: 4.562

The C. elegans gon-2 gene encodes a putative TRP cation channel protein required for mitotic cell cycle progression.

1. Regulation of melastatin, a TRP-related protein, through interaction with a cytoplasmic isoform.

Review 2. Emerging roles of TRPM6/TRPM7 channel kinase signal transduction complexes.

3. Differential regulation of TRPM channels governs electrolyte homeostasis in the C. elegans intestine.

Review 4. Invertebrate TRP proteins as functional models for mammalian channels.

5. Magnesium excretion in C. elegans requires the activity of the GTL-2 TRPM channel.

6. The promotion of gonadal cell divisions by the Caenorhabditis elegans TRPM cation channel GON-2 is antagonized by GEM-4 copine.

Review 7. Function and regulation of TRP family channels in C. elegans.

8. TRPM channels modulate epileptic-like convulsions via systemic ion homeostasis.

9. Highly Ca2+-selective TRPM channels regulate IP3-dependent oscillatory Ca2+ signaling in the C. elegans intestine.

10. TRPM channels are required for rhythmicity in the ultradian defecation rhythm of C. elegans.