Biomonitoring of persons exposed to insecticides used in residences.

Pesticides used indoors inevitably result in some unintentional and unavoidable exposures of residents. Measured dosages of residents are well below toxic levels. Exposures (microg/kg-day) are substantially less and occur over a longer time than suggested by unvalidated estimates derived from previous extreme, conservative default assumptions based solely on environmental residues. Human chlorpyrifos exposures were monitored following three different types of applications: fogger, broadcast, and crack-and-crevice. Persistence of total residue on carpet was substantially greater than the persistence of transferable residue (microg/cm(2)). Low-level (microg/kg) exposures of family members persisted for periods of weeks to a month after pesticide use. Although few children who resided with their parents in pest-protected homes have been monitored, they eliminated more biomarker than their parents on a kg body weight-day basis when absorbed dosages (microg/kg-day) were derived from spot urine specimens corrected for volume by an age-specific creatinine correction. Ultimately environmental residues may become useful elements of predictive residential exposure models, but their potential contribution to indirect exposure assessments must include careful determination of residue availability for contact transfer to clothing or skin and biological validation. When environmental data from monitoring studies reported here were used to estimate residential exposure according to Residential Exposure Assessment Standard Operating Procedures (SAP meeting, 1997), measured exposures were substantially less than assessments. Experimental and situational monitoring of exposed persons is essential for meaningful and responsible predictive resident exposure model building.