OBJECTIVE: To explore whether the presence of Chlamydia trachomatis antibodies is associated with the severity of neoplastic lesions in women with cervical dyskaryosis. METHODS: In a cross sectional study in two groups of women referred for an abnormal Papanicolaou smear (group A: 296, group B: 331 women) blood samples were analysed for antichlamydial antibodies by enzyme immunoassay. Cervical neoplasia was graded histologically. RESULTS: In group A no association was found between increasing grade of CIN and the presence of antichlamydial antibodies. The proportion (93%) of women with antichlamydial antibodies was higher in 14 women with (micro)invasive carcinoma than in women with CIN (35%). As the high prevalence of antichlamydial antibodies in women with cervical carcinoma is not consistent with prevalences reported in recent literature, we analysed a second group of women in which indeed the high prevalence was not confirmed CONCLUSION: Our results suggest that the presence of circulating antichlamydial antibodies is not associated with the severity of neoplastic lesions and it seems unlikely that C trachomatis has a role in the progression of cervical neoplasia.
OBJECTIVE: To explore whether the presence of Chlamydia trachomatis antibodies is associated with the severity of neoplastic lesions in women with cervical dyskaryosis. METHODS: In a cross sectional study in two groups of women referred for an abnormal Papanicolaou smear (group A: 296, group B: 331 women) blood samples were analysed for antichlamydial antibodies by enzyme immunoassay. Cervical neoplasia was graded histologically. RESULTS: In group A no association was found between increasing grade of CIN and the presence of antichlamydial antibodies. The proportion (93%) of women with antichlamydial antibodies was higher in 14 women with (micro)invasive carcinoma than in women with CIN (35%). As the high prevalence of antichlamydial antibodies in women with cervical carcinoma is not consistent with prevalences reported in recent literature, we analysed a second group of women in which indeed the high prevalence was not confirmed CONCLUSION: Our results suggest that the presence of circulating antichlamydial antibodies is not associated with the severity of neoplastic lesions and it seems unlikely that C trachomatis has a role in the progression of cervical neoplasia.
Authors: P Koskela; T Anttila; T Bjørge; A Brunsvig; J Dillner; M Hakama; T Hakulinen; E Jellum; M Lehtinen; P Lenner; T Luostarinen; E Pukkala; P Saikku; S Thoresen; L Youngman; J Paavonen Journal: Int J Cancer Date: 2000-01-01 Impact factor: 7.396
Authors: K M Stone; A Zaidi; L Rosero-Bixby; M W Oberle; G Reynolds; S Larsen; A J Nahmias; F K Lee; J Schachter; M E Guinan Journal: Epidemiology Date: 1995-07 Impact factor: 4.822
Authors: V Moreno; N Muñoz; F X Bosch; S de Sanjosé; L C Gonzalez; L Tafur; M Gili; I Izarzugaza; C Navarro; A Vergara Journal: Cancer Epidemiol Biomarkers Prev Date: 1995 Jul-Aug Impact factor: 4.254
Authors: M Hakama; M Lehtinen; P Knekt; A Aromaa; P Leinikki; A Miettinen; J Paavonen; R Peto; L Teppo Journal: Am J Epidemiol Date: 1993-01-15 Impact factor: 4.897