Literature DB >> 11287591

PR domain of rous sarcoma virus Gag causes an assembly/budding defect in insect cells.

M C Johnson1, H M Scobie, V M Vogt.   

Abstract

While baculovirus expression of Gag proteins from numerous retroviruses has led reliably to production of virus-like particles (VLPs), we observed that expression of Rous sarcoma virus Gag failed to produce VLPs. Transmission and scanning electron microscopy analysis revealed that the Gag protein reached the plasma membrane but was unable to correctly form particles. Addition of a myristylation signal had no effect on the budding defect, but deletion of the PR domain of Gag restored normal budding. The resulting VLPs were morphologically distinct from human immunodeficiency virus type 1 VLPs expressed in parallel.

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Year:  2001        PMID： 11287591      PMCID： PMC114187          DOI： 10.1128/JVI.75.9.4407-4412.2001

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  32 in total

1.  Mass determination of rous sarcoma virus virions by scanning transmission electron microscopy.

Authors:  V M Vogt; M N Simon
Journal:  J Virol       Date:  1999-08       Impact factor: 5.103

2.  Proteolytic activity of purified avian sarcoma and leukemia virus NC-PR protein expressed in Escherichia coli.

Authors:  M Séllos-Moura; V M Vogt
Journal:  Virology       Date:  1996-07-15       Impact factor: 3.616

3.  Proteolytic activity in vivo and encapsidation of recombinant human immunodeficiency virus type 1 proteinase expressed in baculovirus-infected cells.

Authors:  M Royer; M Bardy; B Gay; J Tournier; P Boulanger
Journal:  J Gen Virol       Date:  1997-01       Impact factor: 3.891

4.  A conformational switch controlling HIV-1 morphogenesis.

Authors:  I Gross; H Hohenberg; T Wilk; K Wiegers; M Grättinger; B Müller; S Fuller; H G Kräusslich
Journal:  EMBO J       Date:  2000-01-04       Impact factor: 11.598

5.  Characterization of human endogenous retrovirus type K virus-like particles generated from recombinant baculoviruses.

Authors:  R R Tönjes; K Boller; C Limbach; R Lugert; R Kurth
Journal:  Virology       Date:  1997-07-07       Impact factor: 3.616

6.  Cloning, expression and purification of a recombinant poly-histidine-linked HIV-1 protease.

Authors:  A Leuthardt; J L Roesel
Journal:  FEBS Lett       Date:  1993-07-12       Impact factor: 4.124

7.  Characterization of Rous sarcoma virus Gag particles assembled in vitro.

Authors:  F Yu; S M Joshi; Y M Ma; R L Kingston; M N Simon; V M Vogt
Journal:  J Virol       Date:  2001-03       Impact factor: 5.103

8.  In vitro assembly of virus-like particles with Rous sarcoma virus Gag deletion mutants: identification of the p10 domain as a morphological determinant in the formation of spherical particles.

Authors:  S Campbell; V M Vogt
Journal:  J Virol       Date:  1997-06       Impact factor: 5.103

9.  Differential budding efficiencies of human T-cell leukemia virus type I (HTLV-I) Gag and Gag-Pro polyproteins from insect and mammalian cells.

Authors:  F Bouamr; L Garnier; F Rayne; A Verna; N Rebeyrotte; M Cerutti; R Z Mamoun
Journal:  Virology       Date:  2000-12-20       Impact factor: 3.616

10.  Evidence for a second function of the MA sequence in the Rous sarcoma virus Gag protein.

Authors:  L J Parent; C B Wilson; M D Resh; J W Wills
Journal:  J Virol       Date:  1996-02       Impact factor: 5.103
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  9 in total

1.  Nucleic acid-independent retrovirus assembly can be driven by dimerization.

Authors:  Marc C Johnson; Heather M Scobie; Yu May Ma; Volker M Vogt
Journal:  J Virol       Date:  2002-11       Impact factor: 5.103

2.  In vitro assembly of virus-like particles of a gammaretrovirus, the murine leukemia virus XMRV.

Authors:  Romana Hadravová; Alex de Marco; Pavel Ulbrich; Jitka Stokrová; Michal Dolezal; Iva Pichová; Tomás Ruml; John A G Briggs; Michaela Rumlová
Journal:  J Virol       Date:  2011-11-16       Impact factor: 5.103

3.  Distinct Particle Morphologies Revealed through Comparative Parallel Analyses of Retrovirus-Like Particles.

Authors:  Jessica L Martin; Sheng Cao; Jose O Maldonado; Wei Zhang; Louis M Mansky
Journal:  J Virol       Date:  2016-08-26       Impact factor: 5.103

4.  The retroviral capsid domain dictates virion size, morphology, and coassembly of gag into virus-like particles.

Authors:  Danso Ako-Adjei; Marc C Johnson; Volker M Vogt
Journal:  J Virol       Date:  2005-11       Impact factor: 5.103

5.  Mutations in the spacer peptide and adjoining sequences in Rous sarcoma virus Gag lead to tubular budding.

Authors:  Paul W Keller; Marc C Johnson; Volker M Vogt
Journal:  J Virol       Date:  2008-04-30       Impact factor: 5.103

6.  Hydrodynamic and Membrane Binding Properties of Purified Rous Sarcoma Virus Gag Protein.

Authors:  Robert A Dick; Siddhartha A K Datta; Hirsh Nanda; Xianyang Fang; Yi Wen; Marilia Barros; Yun-Xing Wang; Alan Rein; Volker M Vogt
Journal:  J Virol       Date:  2015-08-05       Impact factor: 5.103

Review 7.  Virus-like particles: models for assembly studies and foreign epitope carriers.

Authors:  Andrzej Palucha; Adrianna Loniewska; Subbian Satheshkumar; Anna M Boguszewska-Chachulska; Mahadevaiah Umashankar; Malgorzata Milner; Anne-Lise Haenni; Handanahal Subbarao Savithri
Journal:  Prog Nucleic Acid Res Mol Biol       Date:  2005

8.  A large extension to HIV-1 Gag, like Pol, has negative impacts on virion assembly.

Authors:  Hiyori Haraguchi; Takeshi Noda; Yoshihiro Kawaoka; Yuko Morikawa
Journal:  PLoS One       Date:  2012-10-23       Impact factor: 3.240

Review 9.  Virus-like particles as a vaccine delivery system: myths and facts.

Authors:  Polly Roy; Rob Noad
Journal:  Adv Exp Med Biol       Date:  2009       Impact factor: 2.622
  9 in total

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