Literature DB >> 11287117

Heme oxygenase-1 induction by nitric oxide in RAW 264.7 macrophages is upregulated by a cyclo-oxygenase-2 inhibitor.

M J Alcaraz1, A Habib, C Créminon, A M Vicente, M Lebret, S Lévy-Toledano, J Maclouf.   

Abstract

Unstimulated RAW 264.7 macrophages express negligible heme oxygenase-1 (HO-1) protein but incubation with the nitric oxide (NO) donor spermine nonoate (SPNO) induced HO-1 and weakly cyclo-oxygenase-2 (COX-2) protein. This effect was potentiated by coincubation with the COX-2 selective inhibitor, SC58125. Cells incubated with SPNO showed a strong increase in HO-1 mRNA levels after 4 h with a significant potentiation in the presence of SC58125, which did not modify HO-1 mRNA stability. The induction of HO-1 by NO and its potentiation by anti-inflammatory agents may play a role in inflammatory and immune responses.

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Year:  2001        PMID： 11287117     DOI： 10.1016/s0304-4165(01)00112-x

Source DB:  PubMed          Journal:  Biochim Biophys Acta        ISSN： 0006-3002


  8 in total

1.  Analysis of heme oxygenase isomers in rat.

Authors:  Zhen-Wei Xia; Wen-Jun Cui; Xue-Hong Zhang; Qing-Xiang Shen; Jian Wang; Yun-Zhu Li; Shen-Nian Chen; Shan-Chang Yu
Journal:  World J Gastroenterol       Date:  2002-12       Impact factor: 5.742

2.  Role of nuclear factor-kappaB and heme oxygenase-1 in the mechanism of action of an anti-inflammatory chalcone derivative in RAW 264.7 cells.

Authors:  María José Alcaraz; Ana María Vicente; Amparo Araico; José N Dominguez; María Carmen Terencio; María Luisa Ferrándiz
Journal:  Br J Pharmacol       Date:  2004-07-12       Impact factor: 8.739

Review 3.  Biliverdin reductase: new features of an old enzyme and its potential therapeutic significance.

Authors:  Urszula M Florczyk; Alicja Jozkowicz; Jozef Dulak
Journal:  Pharmacol Rep       Date:  2008 Jan-Feb       Impact factor: 3.024

4.  Mycobacterium tuberculosis senses host-derived carbon monoxide during macrophage infection.

Authors:  Michael U Shiloh; Paolo Manzanillo; Jeffery S Cox
Journal:  Cell Host Microbe       Date:  2008-05-15       Impact factor: 21.023

5.  Induction of heme oxygenase-1 attenuates lipopolysaccharide-induced cyclooxygenase-2 expression in mouse brain endothelial cells.

Authors:  Ruey-Horng Shih; Chuen-Mao Yang
Journal:  J Neuroinflammation       Date:  2010-11-30       Impact factor: 8.322

6.  Interactions of the gasotransmitters contribute to microvascular tone (dys)regulation in the preterm neonate.

Authors:  Rebecca M Dyson; Hannah K Palliser; Joanna L Latter; Megan A Kelly; Grazyna Chwatko; Rafal Glowacki; Ian M R Wright
Journal:  PLoS One       Date:  2015-03-25       Impact factor: 3.240

7.  Heme oxygenase-1-Dependent anti-inflammatory effects of atorvastatin in zymosan-injected subcutaneous air pouch in mice.

Authors:  Ghewa A El-Achkar; May F Mrad; Charbel A Mouawad; Bassam Badran; Ayad A Jaffa; Roberto Motterlini; Eva Hamade; Aida Habib
Journal:  PLoS One       Date:  2019-05-09       Impact factor: 3.240

8.  Role of nitric oxide and CCAAT/enhancer-binding protein transcription factor in statin-dependent induction of heme oxygenase-1 in mouse macrophages.

Authors:  Charbel A Mouawad; May F Mrad; Moustafa Al-Hariri; Hiba Soussi; Eva Hamade; Jawed Alam; Aïda Habib
Journal:  PLoS One       Date:  2013-05-22       Impact factor: 3.240
  8 in total

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