| Literature DB >> 11286727 |
P K Das1, R M van den Wijngaard, A Wankowicz-Kalinska, I C Le Poole.
Abstract
Vitiligo is a skin disease in which melanocytes (MCs) are eradicated from lesional epidermis, resulting in disfiguring loss of pigment. MCs are destroyed by MC-reactive T cells, as well as other non-immune and immune components. Similarities exist between the autoimmunity observed in vitiligo and the tumour immunity observed in melanoma immuno-surveillance. An analysis of these mechanisms might lead to the development of new therapies for both vitiligo and melanoma.Entities:
Mesh:
Year: 2001 PMID: 11286727 DOI: 10.1016/s1471-4906(00)01844-5
Source DB: PubMed Journal: Trends Immunol ISSN: 1471-4906 Impact factor: 16.687