| Literature DB >> 11286706 |
R Gerli1, C Lunardi, F Vinante, O Bistoni, G Pizzolo, C Pitzalis.
Abstract
CD30 has been proposed to identify Th0/2-type clones. However, the in vivo relevance of this finding is still a matter of debate, as high serum levels of soluble CD30 have been found in both Th1- and Th2- dominated disorders. Among these, rheumatoid arthritis represents a condition where the Th1 predominance is combined with the presence of CD30(+) T-cell activity, particularly in specific stages of the disease. This article discusses the hypothesis that CD30(+) T cells might play a counter-regulatory role at sites of inflammation in Th1-mediated conditions, such as rheumatoid arthritis.Entities:
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Year: 2001 PMID： 11286706 DOI： 10.1016/s1471-4906(00)01829-9
Source DB: PubMed Journal: Trends Immunol ISSN： 1471-4906 Impact factor: 16.687